{"text_format":"3","workbook":"xlsx","n_sheets":4,"sheets":["Virulence factors","Antibiotic resistance","Pathogen host interactions ","Secretion systems"],"not_rendered":{"defined_names":1},"read":"whole","date_system":"1900"}

{"sheet":"Virulence factors","index":0,"n_rows":523,"n_cols":4,"rows_kept":523}
["Excel S2. Human disease-related systems of the K. pneumoniae NKU_KlebA1. Virulence factors (A)."]
["Gene ID","VFDB ID","VFs","Description"]
["gene0027","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene0035","VFG000168(gi:15599424)","Pyochelin","pyochelin biosynthesis protein PchD"]
["gene0054","VFG002059(gi:15595271)","HSI-I","type six secretion associated protein TagT, ATP-binding component of ABC transporter"]
["gene0064","VFG000936(gi:26249458)","Aerobactin","ferric aerobactin receptor precusor IutA"]
["gene0065","VFG000619(gi:56480401)","Aerobactin","aerobactin receptor IutA"]
["gene0086","VFG011430(gi:17987758)","LPS","acyl carrier protein"]
["gene0087","VFG005767(gi:22536831)","Beta-hemolysin/cytolysin","3-ketoacyl-ACP-reductase CylG"]
["gene0117","VFG013436(gi:30995456)","LOS","lipid A biosynthesis lauroyl acyltransferase"]
["gene0133","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene0224","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene0233","VFG045467(gi:53718898)","CdpA","cyclic di-GMP phosphodiesterase"]
["gene0252","VFG001443(gi:7188818)","OmpA","outer membrane protein A"]
["gene0261","VFG002176(gi:21693305)","Cytolysin","ABC-type transporter"]
["gene0271","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene0297","VFG013236(gi:16272032)","LOS","3-deoxy-manno-octulosonate cytidylyltransferase"]
["gene0300","VFG013242(gi:16272033)","LOS","tetraacyldisaccharide 4'-kinase"]
["gene0301","VFG013248(gi:16272034)","LOS","lipid transporter ATP-binding/permease"]
["gene0302","VFG013248(gi:16272034)","LOS","lipid transporter ATP-binding/permease"]
["gene0329","VFG000366(gi:16122162)","Yersiniabactin","inner membrane ABC-transporter YbtQ"]
["gene0330","VFG013248(gi:16272034)","LOS","lipid transporter ATP-binding/permease"]
["gene0333","VFG000080(gi:16803037)","ClpE","ATP-dependent protease"]
["gene0334","VFG002480(gi:53722524)","T6SS-1","Clp-type ATPase chaperone protein"]
["gene0337","VFG002059(gi:15595271)","HSI-I","type six secretion associated protein TagT, ATP-binding component of ABC transporter"]
["gene0357","VFG007023(gi:15641459)","RTX toxin","RTX toxin transporter RtxB"]
["gene0364","VFG001386(gi:15607897)","PhoP","Possible two component system response transcriptional positive regulator PhoP"]
["gene0371","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene0387","VFG045330(gi:52841554)","Legiobactin","LbtC inner membrane protein required for import of Legiobactin"]
["gene0404","VFG007023(gi:15641459)","RTX toxin","RTX toxin transporter RtxB"]
["gene0405","VFG012509(gi:26247127)","Salmochelin","ATP binding cassette transporter"]
["gene0418","VFG002176(gi:21693305)","Cytolysin","ABC-type transporter"]
["gene0431","VFG000354(gi:16123096)","Ail","attachment invasion locus protein"]
["gene0437","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene0451","VFG000700(gi:30962648)","Capsule","bifunctional; ribulose 5-phosphate reductase; CDP-ribitol pyrophosphorylase"]
["gene0458","VFG005776(gi:22536834)","Beta-hemolysin/cytolysin","ABC (ATP-binding cassette) transporter CylA"]
["gene0474","VFG043392(gi:218561919)","Pse5Ac7Ac, Pse5Ac7Am, Pse8OAc, Pse5Am7AcGlnAc","phosphoethanolamine transferase"]
["gene0476","VFG001386(gi:15607897)","PhoP","Possible two component system response transcriptional positive regulator PhoP"]
["gene0495","VFG000574(gi:16767047)","MgtBC","Mg2+ transport protein"]
["gene0496","VFG000574(gi:16767047)","MgtBC","Mg2+ transport protein"]
["gene0499","VFG036992(gi:15677562)","MtrCDE","multiple transferable resistance system protein MtrD"]
["gene0513","VFG012509(gi:26247127)","Salmochelin","ATP binding cassette transporter"]
["gene0518","VFG009579(gi:15608489)","mycobactin","Iron-regulated transporter IrtB"]
["gene0519","VFG013286(gi:16272302)","LOS","UDP-glucose 4-epimerase"]
["gene0520","VFG013286(gi:16272302)","LOS","UDP-glucose 4-epimerase"]
["gene0539","VFG001931(gi:15792793)","CadF","outer membrane fibronectin-binding protein"]
["gene0570","VFG001857(gi:52840983)","IraAB","Di/tripeptide permease"]
["gene0580","VFG002525(gi:53720910)","Flagella","chemotaxis protein CheY"]
["gene0622","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene0626","VFG000001(gi:33592927)","FHA","filamentous hemagglutinin/adhesin"]
["gene0673","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene0675","VFG012509(gi:26247127)","Salmochelin","ATP binding cassette transporter"]
["gene0699","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene0707","VFG000934(gi:26246575)","Enterobactin","2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase"]
["gene0708","VFG000933(gi:26246574)","Enterobactin","isochorismatase"]
["gene0709","VFG000932(gi:26246573)","Enterobactin","2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex"]
["gene0710","VFG000931(gi:26246572)","Enterobactin","isochorismate synthase 1"]
["gene0711","VFG000924(gi:26246571)","Enterobactin","ferrienterobactin ABC transporter periplasmic binding protein"]
["gene0712","VFG044165(gi:26246570)","enterobactin","enterobactin exporter, iron-regulated"]
["gene0713","VFG000926(gi:26246569)","Enterobactin","ferrienterobactin ABC transporter permease"]
["gene0714","VFG000928(gi:26246568)","Enterobactin","iron-enterobactin ABC transporter permease"]
["gene0715","VFG000925(gi:26246567)","Enterobactin","ferrienterobactin ABC transporter ATPase"]
["gene0716","VFG000930(gi:26246565)","Enterobactin","enterobactin synthase multienzyme complex component, ATP-dependent"]
["gene0717","VFG000930(gi:26246565)","Enterobactin","enterobactin synthase multienzyme complex component, ATP-dependent"]
["gene0719","VFG044159(gi:26246563)","enterobactin","enterobactin/ferric enterobactin esterase"]
["gene0720","VFG000923(gi:26246561)","Enterobactin","ferrienterobactin outer membrane transporter"]
["gene0721","VFG000923(gi:26246561)","Enterobactin","ferrienterobactin outer membrane transporter"]
["gene0722","VFG000929(gi:26246560)","Enterobactin","phosphopantetheinyl transferase component of enterobactin synthase multienzyme complex"]
["gene0723","VFG000929(gi:26246560)","Enterobactin","phosphopantetheinyl transferase component of enterobactin synthase multienzyme complex"]
["gene0731","VFG000366(gi:16122162)","Yersiniabactin","inner membrane ABC-transporter YbtQ"]
["gene0733","VFG005767(gi:22536831)","Beta-hemolysin/cytolysin","3-ketoacyl-ACP-reductase CylG"]
["gene0751","VFG000907(gi:26249408)","Hemolysin","Hemolysin B"]
["gene0752","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene0755","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene0763","VFG000925(gi:26246567)","Enterobactin","ferrienterobactin ABC transporter ATPase"]
["gene0765","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene0773","VFG036992(gi:15677562)","MtrCDE","multiple transferable resistance system protein MtrD"]
["gene0775","VFG036974(gi:15677563)","MtrCDE","membrane fusion protein MtrC"]
["gene0777","VFG000574(gi:16767047)","MgtBC","Mg2+ transport protein"]
["gene0778","VFG000574(gi:16767047)","MgtBC","Mg2+ transport protein"]
["gene0792","VFG001248(gi:15596294)","Flagella","transcriptional regulator FleQ"]
["gene0795","VFG036956(gi:15676236)","FarAB","fatty acid efflux system protein FarB"]
["gene0818","VFG001444(gi:9965749)","AslA","putative arylsulfatase"]
["gene0835","VFG000928(gi:26246568)","Enterobactin","iron-enterobactin ABC transporter permease"]
["gene0837","VFG001269(gi:33591935)","Cya","cyclolysin secretion ATP-binding protein"]
["gene0850","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene0855","VFG000038(gi:33591351)","LPS","probable oxidoreductase"]
["gene0867","VFG013436(gi:30995456)","LOS","lipid A biosynthesis lauroyl acyltransferase"]
["gene0870","VFG042537(gi:1232060)","F17 pili","F17 fimbrial uscher"]
["gene0871","VFG042536(gi:1232059)","F17 pili","F17 fimbrial chaperone"]
["gene0872","VFG001147(gi:535168)","Haemagglutinating pili","minor structural protein"]
["gene0901","VFG013321(gi:16272676)","LOS","UDP-2,3-diacylglucosamine pyrophosphohydrolase"]
["gene0910","VFG009579(gi:15608489)","mycobactin","Iron-regulated transporter IrtB"]
["gene0915","VFG002059(gi:15595271)","HSI-I","type six secretion associated protein TagT, ATP-binding component of ABC transporter"]
["gene0920","VFG000574(gi:16767047)","MgtBC","Mg2+ transport protein"]
["gene0941","VFG017856(gi:123443687)","Type IV pili","type IV fimbrial biogenesis protein PilW"]
["gene0944","VFG036974(gi:15677563)","MtrCDE","membrane fusion protein MtrC"]
["gene0945","VFG036992(gi:15677562)","MtrCDE","multiple transferable resistance system protein MtrD"]
["gene0949","VFG001306(gi:21281862)","Capsule","capsular polysaccharide synthesis enzyme Cap8J"]
["gene0956","VFG002197(gi:29375537)","BopD","sugar-binding transcriptional regulator, LacI family"]
["gene0966","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene0969","VFG045467(gi:53718898)","CdpA","cyclic di-GMP phosphodiesterase"]
["gene0985","VFG007023(gi:15641459)","RTX toxin","RTX toxin transporter RtxB"]
["gene0987","VFG001269(gi:33591935)","Cya","cyclolysin secretion ATP-binding protein"]
["gene1000","VFG000077(gi:16804506)","ClpP","ATP-dependent Clp protease proteolytic subunit"]
["gene1067","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene1073","VFG001386(gi:15607897)","PhoP","Possible two component system response transcriptional positive regulator PhoP"]
["gene1107","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene1108","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene1124","VFG005776(gi:22536834)","Beta-hemolysin/cytolysin","ABC (ATP-binding cassette) transporter CylA"]
["gene1125","VFG002181(gi:29376978)","Capsule","ABC transporter, ATP-binding protein"]
["gene1129","VFG000907(gi:26249408)","Hemolysin","Hemolysin B"]
["gene1131","VFG002417(gi:15799994)","ECP","E. coli common pilus chaperone EcpE"]
["gene1132","VFG002416(gi:15799995)","ECP","polymerized tip adhesin of ECP fibers"]
["gene1133","VFG002415(gi:15799996)","ECP","E. coli common pilus usher EcpC"]
["gene1134","VFG002412(gi:15799997)","ECP","E. coli common pilus chaperone EcpB"]
["gene1135","VFG002414(gi:15799998)","ECP","E. coli common pilus structural subunit EcpA"]
["gene1136","VFG002413(gi:15799999)","ECP","regulator protein EcpR"]
["gene1138","VFG002059(gi:15595271)","HSI-I","type six secretion associated protein TagT, ATP-binding component of ABC transporter"]
["gene1198","VFG013418(gi:16273103)","LOS","phosphoheptose isomerase"]
["gene1212","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene1220","VFG002552(gi:53720402)","Capsule I","D-glycero-d-manno-heptose 1,7-bisphosphate phosphatase"]
["gene1221","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene1223","VFG045346(gi:37679074)","IlpA","immunogenic lipoprotein A "]
["gene1238","VFG013384(gi:16272991)","LOS","lipid-A-disaccharide synthase"]
["gene1239","VFG013390(gi:16272992)","LOS","UDP-N-acetylglucosamine acyltransferase"]
["gene1240","VFG011399(gi:17987115)","LPS","(3R)-hydroxymyristoyl ACP dehydratase"]
["gene1241","VFG013374(gi:16272852)","LOS","UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase"]
["gene1244","VFG015000(gi:15598845)","Alginate regulation","metalloprotease protease"]
["gene1245","VFG002189(gi:29376986)","Capsule","phosphatidate cytidylyltransferase"]
["gene1246","VFG002190(gi:29376987)","Capsule","undecaprenyl diphosphate synthase"]
["gene1259","VFG014950(gi:15595963)","Alginate regulation","serine protease MucD precursor"]
["gene1271","VFG001322(gi:21282745)","Isd","iron-regulated surface determinant protein F, ATP-binding-cassette-type transmembrane transporter"]
["gene1273","VFG000925(gi:26246567)","Enterobactin","ferrienterobactin ABC transporter ATPase"]
["gene1283","VFG002047(gi:82778251)","T2SS","general secretion pathway protein D"]
["gene1284","VFG002047(gi:82778251)","T2SS","general secretion pathway protein D"]
["gene1285","VFG000182(gi:15598299)","xcp secretion system","general secretion pathway protein E"]
["gene1286","VFG002049(gi:82778253)","T2SS","general secretion pathway protein F"]
["gene1287","VFG002050(gi:82778254)","T2SS","general secretion pathway protein G"]
["gene1288","VFG002050(gi:82778254)","T2SS","general secretion pathway protein G"]
["gene1291","VFG000177(gi:15598294)","xcp secretion system","general secretion pathway protein J"]
["gene1292","VFG002054(gi:82778258)","T2SS","general secretion pathway protein K"]
["gene1297","VFG002428(gi:53720619)","Type IV pili","type IV prepilin leader peptide type M1"]
["gene1312","VFG005776(gi:22536834)","Beta-hemolysin/cytolysin","ABC (ATP-binding cassette) transporter CylA"]
["gene1313","VFG005776(gi:22536834)","Beta-hemolysin/cytolysin","ABC (ATP-binding cassette) transporter CylA"]
["gene1343","VFG010459(gi:52842133)","type IV pili","type IV pilus  assembly protein, major pilin "]
["gene1344","VFG001880(gi:52841752)","Type IV pili","type IV pilus assembly protein PilB"]
["gene1345","VFG001870(gi:52841593)","lsp T2SS","general secretion pathway protein F"]
["gene1354","VFG013412(gi:16273070)","LOS","UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase"]
["gene1396","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene1460","VFG001226(gi:15595606)","Type IV pili","twitching motility protein PilH"]
["gene1464","VFG001386(gi:15607897)","PhoP","Possible two component system response transcriptional positive regulator PhoP"]
["gene1471","VFG044172(gi:26250140)","Chu","ATP-binding hydrophilic protein ChuV"]
["gene1476","VFG002158(gi:16802971)","LplA1","lipoate protein ligase"]
["gene1513","VFG017856(gi:123443687)","Type IV pili","type IV fimbrial biogenesis protein PilW"]
["gene1520","VFG002085(gi:15600888)","T6SS","type VI secretion system regulatory protein VasH"]
["gene1542","VFG044081(gi:15597452)","pyoverdine","paerucumarin biosynthesis protein PvcC"]
["gene1549","VFG017856(gi:123443687)","Type IV pili","type IV fimbrial biogenesis protein PilW"]
["gene1561","VFG045489(gi:52840512)","Dot/Icm","Dot/Icm type IV secretion system effector"]
["gene1576","VFG006717(gi:16803674)","Lap","Listeria adhesion protein Lap"]
["gene1578","VFG006717(gi:16803674)","Lap","Listeria adhesion protein Lap"]
["gene1591","VFG036938(gi:15676235)","FarAB","fatty acid efflux system protein FarA"]
["gene1592","VFG005776(gi:22536834)","Beta-hemolysin/cytolysin","ABC (ATP-binding cassette) transporter CylA"]
["gene1593","VFG005776(gi:22536834)","Beta-hemolysin/cytolysin","ABC (ATP-binding cassette) transporter CylA"]
["gene1604","VFG009810(gi:15607898)","PhoP/R","Possible two component system response sensor kinase membrane associated PhoR"]
["gene1606","VFG037010(gi:15677561)","MtrCDE","multidrug efflux pump channel protein MtrE"]
["gene1647","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene1683","VFG000574(gi:16767047)","MgtBC","Mg2+ transport protein"]
["gene1684","VFG000574(gi:16767047)","MgtBC","Mg2+ transport protein"]
["gene1685","VFG002197(gi:29375537)","BopD","sugar-binding transcriptional regulator, LacI family"]
["gene1720","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene1742","VFG001234(gi:15595613)","Type IV pili","probable transcriptional regulator"]
["gene1811","VFG001269(gi:33591935)","Cya","cyclolysin secretion ATP-binding protein"]
["gene1814","VFG000858(gi:22001086)","AAFs","periplasmic chaperone"]
["gene1815","VFG000446(gi:16763926)","Type 1 fimbriae","usher protein FimD"]
["gene1820","VFG001855(gi:52840925)","Hsp60","Hsp60, 60K heat shock protein HtpB"]
["gene1842","VFG001285(gi:21284315)","Intercellular adhesion proteins","N-acetylglucosaminyltransferase, involved in polysaccharide intercellular adhesin(PIA) synthesis"]
["gene1867","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene1869","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene1875","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene1883","VFG001386(gi:15607897)","PhoP","Possible two component system response transcriptional positive regulator PhoP"]
["gene1891","VFG001817(gi:15609521)","Mycobactin","Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase"]
["gene1896","VFG000454(gi:16766924)","Lpf","long polar fimbrial usher protein LpfC"]
["gene1898","VFG042424(gi:218921797)","Afimbrial adhesin, AFA-I, mannose-resistant adhesin","chaperone AfaB"]
["gene1908","VFG045467(gi:53718898)","CdpA","cyclic di-GMP phosphodiesterase"]
["gene1914","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene1925","VFG000923(gi:26246561)","Enterobactin","ferrienterobactin outer membrane transporter"]
["gene1926","VFG000923(gi:26246561)","Enterobactin","ferrienterobactin outer membrane transporter"]
["gene1956","VFG005776(gi:22536834)","Beta-hemolysin/cytolysin","ABC (ATP-binding cassette) transporter CylA"]
["gene1980","VFG001381(gi:57116734)","Isocitrate lyase","Isocitrate lyase Icl (isocitrase) (isocitratase)"]
["gene1991","VFG001214(gi:15599743)","Type IV pili","two-component response regulator PilR"]
["gene1992","VFG014369(gi:15596295)","Deoxyhexose linking sugar, 209 Da capping structure","two-component sensor"]
["gene2002","VFG000118(gi:15600448)","Alginate","Alginate regulatory protein AlgQ"]
["gene2074","VFG017856(gi:123443687)","Type IV pili","type IV fimbrial biogenesis protein PilW"]
["gene2105","VFG000033(gi:33591346)","LPS","lipopolysaccharide biosynthesis protein"]
["gene2108","VFG013368(gi:30995408)","LOS","dTDP-glucose 46-dehydratase"]
["gene2109","VFG001311(gi:21281867)","Capsule","capsular polysaccharide synthesis enzyme Cap8O"]
["gene2110","VFG001373(gi:15900286)","Capsule","UDP-N-acetylglucosamine-2-epimerase"]
["gene2112","VFG013508(gi:16273603)","LOS","undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase"]
["gene2134","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene2143","VFG000935(gi:26247124)","IroN","salmochelin receptor IroN"]
["gene2172","VFG002197(gi:29375537)","BopD","sugar-binding transcriptional regulator, LacI family"]
["gene2183","VFG001225(gi:15595605)","Type IV pili","twitching motility protein PilG"]
["gene2184","VFG009810(gi:15607898)","PhoP/R","Possible two component system response sensor kinase membrane associated PhoR"]
["gene2187","VFG001867(gi:52843161)","SodB","superoxide dismutase"]
["gene2196","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene2227","VFG009810(gi:15607898)","PhoP/R","Possible two component system response sensor kinase membrane associated PhoR"]
["gene2228","VFG001214(gi:15599743)","Type IV pili","two-component response regulator PilR"]
["gene2248","VFG002197(gi:29375537)","BopD","sugar-binding transcriptional regulator, LacI family"]
["gene2252","VFG000907(gi:26249408)","Hemolysin","Hemolysin B"]
["gene2268","VFG000515(gi:16764765)","TTSS(SPI-2 encode)","type III secretion system ATPase SsaN"]
["gene2270","VFG007158(gi:28898442)","T3SS1","type III secretion system ATPase VscN"]
["gene2280","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene2334","VFG002440(gi:53722543)","Bsa T3SS","two-component response regulator"]
["gene2338","VFG001089(gi:16802879)","Hpt","hexose phosphate transport protein"]
["gene2339","VFG001089(gi:16802879)","Hpt","hexose phosphate transport protein"]
["gene2350","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene2357","VFG002197(gi:29375537)","BopD","sugar-binding transcriptional regulator, LacI family"]
["gene2370","VFG002026(gi:15792473)","LOS","phosphoheptose isomerase"]
["gene2372","VFG037010(gi:15677561)","MtrCDE","multidrug efflux pump channel protein MtrE"]
["gene2373","VFG036992(gi:15677562)","MtrCDE","multiple transferable resistance system protein MtrD"]
["gene2374","VFG036974(gi:15677563)","MtrCDE","membrane fusion protein MtrC"]
["gene2380","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene2385","VFG045346(gi:37679074)","IlpA","immunogenic lipoprotein A "]
["gene2427","VFG001826(gi:15609720)","RelA","Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase)"]
["gene2428","VFG001826(gi:15609720)","RelA","Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase)"]
["gene2441","VFG005776(gi:22536834)","Beta-hemolysin/cytolysin","ABC (ATP-binding cassette) transporter CylA"]
["gene2455","VFG000320(gi:15646084)","LPS","lipopolysaccharide core biosynthesis protein"]
["gene2456","VFG013315(gi:16272596)","LOS","beta-1,4-glucosyltransferase"]
["gene2457","VFG000330(gi:16272595)","LOS","3-deoxy-d-manno-octulosonic-acid transferase"]
["gene2458","VFG001341(gi:22537322)","Capsule","glycosyl transferase CpsJ(V)"]
["gene2459","VFG013496(gi:16273585)","LOS","glycosyltransferase"]
["gene2468","VFG000142(gi:15600204)","LPS","3-deoxy-D-manno-octulosonic-acid (KDO) transferase"]
["gene2469","VFG013400(gi:16273031)","LOS","ADP-heptose-LPS heptosyltransferase II"]
["gene2470","VFG000332(gi:16273039)","LOS","ADP-L-glycero-D-mannoheptose-6-epimerase"]
["gene2471","VFG002546(gi:53720396)","Capsule I","acyl-CoA transferase"]
["gene2507","VFG012509(gi:26247127)","Salmochelin","ATP binding cassette transporter"]
["gene2508","VFG044172(gi:26250140)","Chu","ATP-binding hydrophilic protein ChuV"]
["gene2521","VFG012509(gi:26247127)","Salmochelin","ATP binding cassette transporter"]
["gene2532","VFG000335(gi:16273088)","P5 protein","outer membrane protein P5 (ompA), human factor H binding protein"]
["gene2546","VFG000907(gi:26249408)","Hemolysin","Hemolysin B"]
["gene2547","VFG000925(gi:26246567)","Enterobactin","ferrienterobactin ABC transporter ATPase"]
["gene2549","VFG002059(gi:15595271)","HSI-I","type six secretion associated protein TagT, ATP-binding component of ABC transporter"]
["gene2552","VFG043385(gi:15645648)","Pse5Ac7Ac","ATP-binding protein "]
["gene2580","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene2584","VFG006717(gi:16803674)","Lap","Listeria adhesion protein Lap"]
["gene2600","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene2601","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene2607","VFG000033(gi:33591346)","LPS","lipopolysaccharide biosynthesis protein"]
["gene2608","VFG001285(gi:21284315)","Intercellular adhesion proteins","N-acetylglucosaminyltransferase, involved in polysaccharide intercellular adhesin(PIA) synthesis"]
["gene2627","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene2630","VFG002319(gi:123442749)","Flagella","flagellar biosynthesis sigma factor"]
["gene2632","VFG016046(gi:15597609)","pyoverdine","diaminobutyrate-2-oxoglutarate aminotransferase PvdH"]
["gene2641","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene2642","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene2648","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene2651","VFG000679(gi:6470206)","Capsule","gamma-glutamyltranspeptidase, required for polyglutamate anchoring to peptidoglycan"]
["gene2684","VFG001859(gi:52842863)","FeoAB","ferrous iron transporter B"]
["gene2689","VFG009810(gi:15607898)","PhoP/R","Possible two component system response sensor kinase membrane associated PhoR"]
["gene2704","VFG010463(gi:52841166)","type IV pili","type IV pilus secretin protein PilQ "]
["gene2721","VFG002241(gi:49476021)","VirB/VirD4 type IV secretion system","Bartonella effector protein BepA"]
["gene2722","VFG015515(gi:15599409)","Phenazines biosynthesis","phenazine biosynthesis protein PhzE"]
["gene2732","VFG002563(gi:53720413)","Capsule I","ATP-binding ABC transporter capsular polysaccharide export protein"]
["gene2793","VFG045340(gi:17987019)","RicA","Rab2 interacting conserved protein A"]
["gene2802","VFG036992(gi:15677562)","MtrCDE","multiple transferable resistance system protein MtrD"]
["gene2803","VFG036974(gi:15677563)","MtrCDE","membrane fusion protein MtrC"]
["gene2827","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene2836","VFG014984(gi:15599642)","Alginate regulation","AlgW protein"]
["gene2837","VFG014984(gi:15599642)","Alginate regulation","AlgW protein"]
["gene2854","VFG009810(gi:15607898)","PhoP/R","Possible two component system response sensor kinase membrane associated PhoR"]
["gene2863","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene2867","VFG001971(gi:15792761)","Capsule","D-arabinose 5-phosphate isomerase"]
["gene2869","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene2892","VFG014893(gi:15600515)","Alginate biosynthesis","phosphomannomutase AlgC"]
["gene2941","VFG001952(gi:15792742)","Capsule","phosphoheptose isomerase"]
["gene2988","VFG001266(gi:15599418)","Pyochelin","ABC transporter ATP-binding protein"]
["gene2994","VFG016046(gi:15597609)","pyoverdine","diaminobutyrate-2-oxoglutarate aminotransferase PvdH"]
["gene3006","VFG043319(gi:52841089)","polar flagella","transcriptional regulator FleQ"]
["gene3009","VFG006717(gi:16803674)","Lap","Listeria adhesion protein Lap"]
["gene3066","VFG002319(gi:123442749)","Flagella","flagellar biosynthesis sigma factor"]
["gene3071","VFG000274(gi:15644698)","Urease","urease accessory protein (ureG)"]
["gene3075","VFG000270(gi:15644702)","Urease","urease beta subunit UreB, urea amidohydrolase"]
["gene3076","VFG000269(gi:15644703)","Urease","urease alpha subunit UreA"]
["gene3077","VFG000269(gi:15644703)","Urease","urease alpha subunit UreA"]
["gene3091","VFG000331(gi:16273426)","LOS","ADP-heptose synthase"]
["gene3092","VFG000331(gi:16273426)","LOS","ADP-heptose synthase"]
["gene3109","VFG009810(gi:15607898)","PhoP/R","Possible two component system response sensor kinase membrane associated PhoR"]
["gene3110","VFG001386(gi:15607897)","PhoP","Possible two component system response transcriptional positive regulator PhoP"]
["gene3140","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene3156","VFG000841(gi:75994495)","Hemolysin","hemolysin transport protein"]
["gene3159","VFG013265(gi:16272217)","LOS","deoxyribonucleotide triphosphate pyrophosphatase"]
["gene3163","VFG000232(gi:15675990)","Type IV pili","twitching motility protein PilT"]
["gene3165","VFG004125(gi:16764498)","curli fibers/thin aggregative fimbriae (AGF)","DNA-binding transcriptional regulator CsgD"]
["gene3169","VFG045607(gi:52843130)","Dot/Icm","Dot/Icm type IV secretion system effector"]
["gene3202","VFG000934(gi:26246575)","Enterobactin","2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase"]
["gene3249","VFG000879(gi:26251208)","Type 1 fimbriae","FimH protein precursor"]
["gene3250","VFG000878(gi:26251207)","Type 1 fimbriae","FimG protein precursor"]
["gene3251","VFG000877(gi:26251205)","Type 1 fimbriae","FimF protein precursor"]
["gene3252","VFG000876(gi:26251204)","Type 1 fimbriae","Outer membrane usher protein fimD precursor"]
["gene3253","VFG000876(gi:26251204)","Type 1 fimbriae","Outer membrane usher protein fimD precursor"]
["gene3254","VFG000875(gi:26251203)","Type 1 fimbriae","Chaperone protein fimC precursor"]
["gene3255","VFG000874(gi:26251202)","Type 1 fimbriae","Fimbrin-like protein fimI precursor"]
["gene3256","VFG000874(gi:26251202)","Type 1 fimbriae","Fimbrin-like protein fimI precursor"]
["gene3257","VFG000873(gi:26251201)","Type 1 fimbriae","Type-1 fimbrial protein, A chain precursor"]
["gene3259","VFG000872(gi:26251200)","Type 1 fimbriae","Type 1 fimbriae Regulatory protein fimE"]
["gene3260","VFG000871(gi:26251199)","Type 1 fimbriae","Type 1 fimbriae Regulatory protein fimB"]
["gene3266","VFG001145(gi:535166)","Haemagglutinating pili","periplasmic chaperone"]
["gene3267","VFG042537(gi:1232060)","F17 pili","F17 fimbrial uscher"]
["gene3271","VFG002440(gi:53722543)","Bsa T3SS","two-component response regulator"]
["gene3276","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene3281","VFG005767(gi:22536831)","Beta-hemolysin/cytolysin","3-ketoacyl-ACP-reductase CylG"]
["gene3290","VFG000907(gi:26249408)","Hemolysin","Hemolysin B"]
["gene3304","VFG002197(gi:29375537)","BopD","sugar-binding transcriptional regulator, LacI family"]
["gene3306","VFG000168(gi:15599424)","Pyochelin","pyochelin biosynthesis protein PchD"]
["gene3335","VFG006717(gi:16803674)","Lap","Listeria adhesion protein Lap"]
["gene3372","VFG007023(gi:15641459)","RTX toxin","RTX toxin transporter RtxB"]
["gene3392","VFG000313(gi:15645788)","LPS","glucose/galactose transporter"]
["gene3395","VFG006717(gi:16803674)","Lap","Listeria adhesion protein Lap"]
["gene3397","VFG001214(gi:15599743)","Type IV pili","two-component response regulator PilR"]
["gene3398","VFG001249(gi:15596296)","Flagella","two-component response regulator"]
["gene3404","VFG000907(gi:26249408)","Hemolysin","Hemolysin B"]
["gene3425","VFG001386(gi:15607897)","PhoP","Possible two component system response transcriptional positive regulator PhoP"]
["gene3426","VFG009810(gi:15607898)","PhoP/R","Possible two component system response sensor kinase membrane associated PhoR"]
["gene3428","VFG001826(gi:15609720)","RelA","Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase)"]
["gene3452","VFG002319(gi:123442749)","Flagella","flagellar biosynthesis sigma factor"]
["gene3456","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene3464","VFG007138(gi:15600788)","VAS","type VI secretion system substrate Hcp-2"]
["gene3465","VFG013070(gi:82778664)","Shu","ATP-binding component of hemin transport system"]
["gene3466","VFG000922(gi:26250139)","Chu","heme permease protein ChuU"]
["gene3467","VFG013065(gi:82778668)","Shu","periplasmic binding protein ShuT"]
["gene3468","VFG000916(gi:26250129)","Chu","heme oxygenase ChuS"]
["gene3478","VFG000925(gi:26246567)","Enterobactin","ferrienterobactin ABC transporter ATPase"]
["gene3479","VFG001359(gi:15901485)","PsaA","manganese ABC transporter, manganese-binding adhesion liprotein"]
["gene3489","VFG043319(gi:52841089)","polar flagella","transcriptional regulator FleQ"]
["gene3517","VFG002085(gi:15600888)","T6SS","type VI secretion system regulatory protein VasH"]
["gene3518","VFG000116(gi:15600676)","Alginate","two-component response regulator AlgB"]
["gene3519","VFG001971(gi:15792761)","Capsule","D-arabinose 5-phosphate isomerase"]
["gene3527","VFG000925(gi:26246567)","Enterobactin","ferrienterobactin ABC transporter ATPase"]
["gene3528","VFG037046(gi:15676493)","MntABC","ABC transporter ATP-binding protein MntA"]
["gene3529","VFG037064(gi:15676492)","MntABC","Manganese transport system membrane protein MntB"]
["gene3530","VFG037082(gi:15676491)","MntABC","periplasmic binding protein MntC"]
["gene3549","VFG036956(gi:15676236)","FarAB","fatty acid efflux system protein FarB"]
["gene3550","VFG036956(gi:15676236)","FarAB","fatty acid efflux system protein FarB"]
["gene3551","VFG036938(gi:15676235)","FarAB","fatty acid efflux system protein FarA"]
["gene3553","VFG042390(gi:91210146)","S fimbriae","regulatory protein SfaX"]
["gene3559","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene3579","VFG002085(gi:15600888)","T6SS","type VI secretion system regulatory protein VasH"]
["gene3586","VFG000877(gi:26251205)","Type 1 fimbriae","FimF protein precursor"]
["gene3587","VFG000455(gi:16766925)","Lpf","long polar fimbrial chaperone protein LpfB"]
["gene3588","VFG000454(gi:16766924)","Lpf","long polar fimbrial usher protein LpfC"]
["gene3589","VFG000876(gi:26251204)","Type 1 fimbriae","Outer membrane usher protein fimD precursor"]
["gene3598","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene3606","VFG036992(gi:15677562)","MtrCDE","multiple transferable resistance system protein MtrD"]
["gene3607","VFG036974(gi:15677563)","MtrCDE","membrane fusion protein MtrC"]
["gene3610","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene3627","VFG037118(gi:15676638)","RecN","DNA repair protein RecN"]
["gene3639","VFG001931(gi:15792793)","CadF","outer membrane fibronectin-binding protein"]
["gene3651","VFG002076(gi:15595288)","HSI-I","type VI secretion system AAA+ family ATPase"]
["gene3674","VFG000121(gi:15595959)","Alginate","alginate biosynthesis protein AlgZ/FimS"]
["gene3677","VFG000136(gi:15595962)","Alginate","negative regulator for alginate biosynthesis MucB"]
["gene3684","VFG043390(gi:15646189)","Pse5Ac7Ac","pyridoxine 5'-phosphate synthase"]
["gene3696","VFG043345(gi:52841989)","polar flagella","sigma 54-dependent response regulator"]
["gene3697","VFG001214(gi:15599743)","Type IV pili","two-component response regulator PilR"]
["gene3738","VFG001859(gi:52842863)","FeoAB","ferrous iron transporter B"]
["gene3749","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene3751","VFG045467(gi:53718898)","CdpA","cyclic di-GMP phosphodiesterase"]
["gene3761","VFG017856(gi:123443687)","Type IV pili","type IV fimbrial biogenesis protein PilW"]
["gene3778","VFG036992(gi:15677562)","MtrCDE","multiple transferable resistance system protein MtrD"]
["gene3815","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene3835","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene3857","VFG000120(gi:15600455)","Alginate","sigma factor AlgU"]
["gene3886","VFG000362(gi:16122158)","Yersiniabactin","yersiniabactin biosynthetic protein Irp1"]
["gene3905","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene3926","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene3947","VFG000931(gi:26246572)","Enterobactin","isochorismate synthase 1"]
["gene3954","VFG017856(gi:123443687)","Type IV pili","type IV fimbrial biogenesis protein PilW"]
["gene3976","VFG043345(gi:52841989)","polar flagella","sigma 54-dependent response regulator"]
["gene3984","VFG000160(gi:15597593)","Pyoverdine","pyoverdine biosynthesis protein PvdE"]
["gene4004","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene4030","VFG000935(gi:26247124)","IroN","salmochelin receptor IroN"]
["gene4034","VFG002197(gi:29375537)","BopD","sugar-binding transcriptional regulator, LacI family"]
["gene4036","VFG001269(gi:33591935)","Cya","cyclolysin secretion ATP-binding protein"]
["gene4061","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene4065","VFG000120(gi:15600455)","Alginate","sigma factor AlgU"]
["gene4066","VFG000119(gi:15600454)","Alginate","alginate biosynthesis regulatory protein AlgR"]
["gene4070","VFG043350(gi:52842010)","polar flagella","flagellar synthesis regulator FleN"]
["gene4073","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene4118","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene4119","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene4124","VFG009810(gi:15607898)","PhoP/R","Possible two component system response sensor kinase membrane associated PhoR"]
["gene4127","VFG036992(gi:15677562)","MtrCDE","multiple transferable resistance system protein MtrD"]
["gene4130","VFG036974(gi:15677563)","MtrCDE","membrane fusion protein MtrC"]
["gene4147","VFG013346(gi:16272753)","LOS","glucosephosphate uridylyltransferase"]
["gene4153","VFG001298(gi:21281854)","Capsule","capsular polysaccharide synthesis enzyme Cap8B"]
["gene4164","VFG002186(gi:29376983)","Capsule","glycosyl transferase, group 2 family protein"]
["gene4166","VFG013365(gi:16272813)","LOS","undecaprenyl-phosphate galactosephosphotransferase"]
["gene4169","VFG000963(gi:15675934)","Hyaluronic acid capsule","UDP-glucose 6-dehydrogenase"]
["gene4174","VFG002181(gi:29376978)","Capsule","ABC transporter, ATP-binding protein"]
["gene4176","VFG002182(gi:29376979)","Capsule","UDP-galactopyranose mutase"]
["gene4179","VFG002186(gi:29376983)","Capsule","glycosyl transferase, group 2 family protein"]
["gene4181","VFG000670(gi:24111748)","LPS","bactoprenol glucosyl transferase"]
["gene4214","VFG045467(gi:53718898)","CdpA","cyclic di-GMP phosphodiesterase"]
["gene4236","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene4261","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene4262","VFG002538(gi:53721911)","Quorum-sensing","N-acylhomoserine lactone dependent regulatory protein"]
["gene4264","VFG001226(gi:15595606)","Type IV pili","twitching motility protein PilH"]
["gene4286","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene4308","VFG044172(gi:26250140)","Chu","ATP-binding hydrophilic protein ChuV"]
["gene4311","VFG013254(gi:16272163)","LOS","lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase"]
["gene4333","VFG045345(gi:28898385)","MAM7","multivalent adhesion molecule MAM7"]
["gene4334","VFG045345(gi:28898385)","MAM7","multivalent adhesion molecule MAM7"]
["gene4368","VFG016058(gi:15597620)","pyoverdine","peptide synthase PvdL"]
["gene4371","VFG011850(gi:15791455)","Flagella","ATP-binding protein"]
["gene4412","VFG005776(gi:22536834)","Beta-hemolysin/cytolysin","ABC (ATP-binding cassette) transporter CylA"]
["gene4413","VFG002176(gi:21693305)","Cytolysin","ABC-type transporter"]
["gene4414","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene4420","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene4431","VFG001931(gi:15792793)","CadF","outer membrane fibronectin-binding protein"]
["gene4445","VFG002479(gi:53722523)","T6SS-1","Type VI secretion system protein TssE"]
["gene4467","VFG013465(gi:16273457)","LOS","2-dehydro-3-deoxyphosphooctonate aldolase"]
["gene4478","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene4481","VFG002307(gi:16765837)","SinH","intimin-like protein"]
["gene4482","VFG000119(gi:15600454)","Alginate","alginate biosynthesis regulatory protein AlgR"]
["gene4498","VFG013346(gi:16272753)","LOS","glucosephosphate uridylyltransferase"]
["gene4502","VFG006717(gi:16803674)","Lap","Listeria adhesion protein Lap"]
["gene4509","VFG007023(gi:15641459)","RTX toxin","RTX toxin transporter RtxB"]
["gene4510","VFG000925(gi:26246567)","Enterobactin","ferrienterobactin ABC transporter ATPase"]
["gene4511","VFG007023(gi:15641459)","RTX toxin","RTX toxin transporter RtxB"]
["gene4541","VFG000922(gi:26250139)","Chu","heme permease protein ChuU"]
["gene4542","VFG045346(gi:37679074)","IlpA","immunogenic lipoprotein A "]
["gene4544","VFG013070(gi:82778664)","Shu","ATP-binding component of hemin transport system"]
["gene4562","VFG000925(gi:26246567)","Enterobactin","ferrienterobactin ABC transporter ATPase"]
["gene4563","VFG000922(gi:26250139)","Chu","heme permease protein ChuU"]
["gene4564","VFG000918(gi:26250135)","Chu","periplasmic heme-binding protein ChuT"]
["gene4593","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene4613","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene4620","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene4622","VFG000925(gi:26246567)","Enterobactin","ferrienterobactin ABC transporter ATPase"]
["gene4623","VFG000926(gi:26246569)","Enterobactin","ferrienterobactin ABC transporter permease"]
["gene4624","VFG000928(gi:26246568)","Enterobactin","iron-enterobactin ABC transporter permease"]
["gene4632","VFG000907(gi:26249408)","Hemolysin","Hemolysin B"]
["gene4646","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene4653","VFG010866(gi:52841093)","Cytochrome c muturation (ccm) locus","ABC transporter involved in cytochrome c biogenesis, CcmB subunit"]
["gene4654","VFG001856(gi:52841094)","CcmC","cytochrome c-type biogenesis protein CcmC, putative heme lyase for CcmE"]
["gene4656","VFG010878(gi:52841096)","Cytochrome c muturation (ccm) locus","cytochrome c-type biogenesis protein CcmE, heme chaperone"]
["gene4657","VFG010882(gi:52841097)","Cytochrome c muturation (ccm) locus","cytochrome c heme lyase subunit CcmF"]
["gene4662","VFG001966(gi:15792756)","Capsule","sugar transferase"]
["gene4663","VFG043346(gi:52841990)","polar flagella","flagellar sensor histidine kinase FleS"]
["gene4664","VFG001225(gi:15595605)","Type IV pili","twitching motility protein PilG"]
["gene4667","VFG036992(gi:15677562)","MtrCDE","multiple transferable resistance system protein MtrD"]
["gene4668","VFG036992(gi:15677562)","MtrCDE","multiple transferable resistance system protein MtrD"]
["gene4699","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene4719","VFG001269(gi:33591935)","Cya","cyclolysin secretion ATP-binding protein"]
["gene4720","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene4754","VFG001867(gi:52843161)","SodB","superoxide dismutase"]
["gene4765","VFG000463(gi:16764404)","SodCI","Gifsy-2 prophage: superoxide dismutase precursor (Cu-Zn)"]
["gene4767","VFG036938(gi:15676235)","FarAB","fatty acid efflux system protein FarA"]
["gene4774","VFG015521(gi:15599412)","Phenazines biosynthesis","phenazine biosynthesis protein PhzG, pyridoxamine 5'-phosphate oxidase"]
["gene4834","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene4859","VFG000358(gi:16122154)","Yersiniabactin","pesticin/yersiniabactin receptor protein"]
["gene4866","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene4874","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene4886","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene4924","VFG013248(gi:16272034)","LOS","lipid transporter ATP-binding/permease"]
["gene4931","VFG002176(gi:21693305)","Cytolysin","ABC-type transporter"]
["gene4964","VFG000575(gi:16767048)","MgtBC","Mg2+ transport protein"]
["gene4967","VFG001861(gi:52840449)","KatAB","catalase/(hydro)peroxidase"]
["gene4984","VFG001386(gi:15607897)","PhoP","Possible two component system response transcriptional positive regulator PhoP"]
["gene4992","VFG016046(gi:15597609)","pyoverdine","diaminobutyrate-2-oxoglutarate aminotransferase PvdH"]
["gene4995","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene5026","VFG005788(gi:22536838)","Beta-hemolysin/cytolysin","putative 3-ketoacyl-ACP synthase CylI"]
["gene5028","VFG036938(gi:15676235)","FarAB","fatty acid efflux system protein FarA"]
["gene5042","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene5043","VFG002059(gi:15595271)","HSI-I","type six secretion associated protein TagT, ATP-binding component of ABC transporter"]
["gene5072","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene5080","VFG000907(gi:26249408)","Hemolysin","Hemolysin B"]
["gene5091","VFG009810(gi:15607898)","PhoP/R","Possible two component system response sensor kinase membrane associated PhoR"]
["gene5092","VFG001214(gi:15599743)","Type IV pili","two-component response regulator PilR"]
["gene5095","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene5117","VFG000161(gi:15597595)","Pyoverdine","pyoverdine synthetase D"]
["gene5119","VFG005767(gi:22536831)","Beta-hemolysin/cytolysin","3-ketoacyl-ACP-reductase CylG"]
["gene5137","VFG012501(gi:26247125)","Salmochelin","esterase"]
["gene5144","VFG000455(gi:16766925)","Lpf","long polar fimbrial chaperone protein LpfB"]
["gene5146","VFG000454(gi:16766924)","Lpf","long polar fimbrial usher protein LpfC"]
["gene5165","VFG045346(gi:37679074)","IlpA","immunogenic lipoprotein A "]
["gene5166","VFG001269(gi:33591935)","Cya","cyclolysin secretion ATP-binding protein"]
["gene5171","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene5182","VFG045467(gi:53718898)","CdpA","cyclic di-GMP phosphodiesterase"]
["gene5193","VFG006717(gi:16803674)","Lap","Listeria adhesion protein Lap"]
["gene5207","VFG000344(gi:16272073)","HitABC","iron(III) ABC transporter, ATP-binding protein"]
["gene5209","VFG044172(gi:26250140)","Chu","ATP-binding hydrophilic protein ChuV"]
["gene5219","VFG002197(gi:29375537)","BopD","sugar-binding transcriptional regulator, LacI family"]
["gene5293","VFG001231(gi:15595610)","Type IV pili","still frameshift probable component of chemotactic signal transduction system"]
["gene5330","VFG002440(gi:53722543)","Bsa T3SS","two-component response regulator"]
["gene5362","VFG016046(gi:15597609)","pyoverdine","diaminobutyrate-2-oxoglutarate aminotransferase PvdH"]
["gene5372","VFG036938(gi:15676235)","FarAB","fatty acid efflux system protein FarA"]
["gene5378","VFG045340(gi:17987019)","RicA","Rab2 interacting conserved protein A"]
["gene5423","VFG000907(gi:26249408)","Hemolysin","Hemolysin B"]
["gene5424","VFG045346(gi:37679074)","IlpA","immunogenic lipoprotein A "]
["gene5439","VFG005767(gi:22536831)","Beta-hemolysin/cytolysin","3-ketoacyl-ACP-reductase CylG"]
["gene5444","VFG002078(gi:15600881)","T6SS","type VI secretion system protein VasA"]
["gene5445","VFG002078(gi:15600881)","T6SS","type VI secretion system protein VasA"]
["gene5467","VFG041011(gi:15595293)","HSI-1 (Hcp-secretion island 1)","type VI secretion system substrate VgrG1b"]
["gene5468","VFG002084(gi:15600887)","T6SS","type VI secretion system AAA+ family ATPase"]
["gene5469","VFG007138(gi:15600788)","VAS","type VI secretion system substrate Hcp-2"]
["gene5474","VFG002093(gi:15600879)","T6SS","type VI secretion system tubule-forming protein VipB"]
["gene5475","VFG002092(gi:15600878)","T6SS","type VI secretion system tubule-forming protein VipA"]
["gene5479","VFG005767(gi:22536831)","Beta-hemolysin/cytolysin","3-ketoacyl-ACP-reductase CylG"]
["gene5486","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene5494","VFG001214(gi:15599743)","Type IV pili","two-component response regulator PilR"]
["gene5504","VFG001248(gi:15596294)","Flagella","transcriptional regulator FleQ"]
["gene5583","VFG002059(gi:15595271)","HSI-I","type six secretion associated protein TagT, ATP-binding component of ABC transporter"]
["gene5584","VFG001206(gi:15677997)","FbpABC","iron(III) ABC transporter, ATP-binding protein"]
["gene5617","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene5631","VFG000935(gi:26247124)","IroN","salmochelin receptor IroN"]
["gene5637","VFG000935(gi:26247124)","IroN","salmochelin receptor IroN"]
["gene5645","VFG037028(gi:15676142)","KatA","catalase"]
["gene5669","VFG002059(gi:15595271)","HSI-I","type six secretion associated protein TagT, ATP-binding component of ABC transporter"]
["gene5676","VFG002548(gi:53720398)","Capsule I","capsular polysaccharide biosynthesis fatty acid synthase"]
["gene5688","VFG037100(gi:15675984)","MsrAB","trifunctional thioredoxin/methionine sulfoxide reductase A/B protein"]
["gene5703","VFG000934(gi:26246575)","Enterobactin","2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase"]
["gene5704","VFG044083(gi:15597454)","pyoverdine","transcriptional regulator PtxR"]
["gene5759","VFG013436(gi:30995456)","LOS","lipid A biosynthesis lauroyl acyltransferase"]

{"sheet":"Antibiotic resistance","index":1,"n_rows":388,"n_cols":4,"rows_kept":388}
["Excel S2. Human disease-related systems of the K. pneumoniae NKU_KlebA1. Antibiotic resistance (B)."]
["Gene ID","ARO Name","ARO Accession","ARO Description"]
["gene0021","Klebsiella mutant PhoP conferring antibiotic resistance to colistin","ARO:3003585","A mutant phoP activates pmrHFIJKLM expression responsible for L-aminoarabinose synthesis and polymyxin resistance"]
["gene0022","Pseudomonas mutant PhoQ conferring resistance to colistin","ARO:3003896","Mutations in Pseudomonas aeruginosa PhoQ of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin"]
["gene0027","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene0054","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene0057","mfd","ARO:3003844","mfd dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. The Mfd (mutation frequency decline) protein"]
["gene0085","Mycobacterium tuberculosis kasA mutant conferring resistance to isoniazid","ARO:3003463","Specific mutations on the Mycobacterium tuberculosis kasA gene resulting in lowered affinity of isoniazid"]
["gene0105","mdtH","ARO:3001216","Multidrug resistance protein MdtH"]
["gene0118","mdtG","ARO:3001329","Efflux protien mdtG."]
["gene0119","mdtG","ARO:3001329","Efflux protien mdtG."]
["gene0261","srmB","ARO:3002828","srmB is an efflux pump found in Streptomyces ambofaciens that confers resistance to spiramycin"]
["gene0271","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance"]
["gene0283","Enterobacter aerogenes omp36 mutants","ARO:3003385","Mutant forms of the porin Omp36 result in reduced permeability to antibiotics."]
["gene0285","PEDO-1","ARO:3003670","PEDO-1 is a subclass B3 metallo-beta lactamase isolated from Pedobacter roseus exhibiting resistance to carbapenems."]
["gene0301","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A"]
["gene0302","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A"]
["gene0329","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A"]
["gene0330","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A"]
["gene0337","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene0338","macA","ARO:3000533","MacA is a membrane fusion protein that forms an antibiotic efflux complex with MacB and TolC."]
["gene0357","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene0362","vanSM","ARO:3002939","vanSM is a vanS variant found in the vanM gene cluster"]
["gene0364","vanRM","ARO:3002928","vanRM is a vanR variant found in the vanM gene cluster"]
["gene0371","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene0375","Escherichia coli nfsA mutations conferring resistance to nitrofurantoin","ARO:3003751","nfsA encodes the major oxygen-insesitive nitroreductase in E. coli. The first step of resistance to nitrofurazone is mutation of nfsA."]
["gene0386","mdfA","ARO:3001328","Multidrug translocase MdfA"]
["gene0387","mdfA","ARO:3001328","Multidrug translocase MdfA"]
["gene0404","efrA","ARO:3003948","efrA is a part of the EfrAB efflux pump"]
["gene0405","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene0418","vgaA","ARO:3002829","vgaA is an efflux protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA."]
["gene0437","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene0458","oleC","ARO:3003748","oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion."]
["gene0474","PmrC","ARO:3003576","PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine"]
["gene0476","PmrA","ARO:3003582","Response regulator for Lipid A modification genes, two-component system involved in polymyxin resistance that senses high extracellular Fe(2+)"]
["gene0498","smeD","ARO:3003055","smeD is the membrane fusion protein of the smeDEF multidrug efflux complex in Stenotrophomonas maltophilia"]
["gene0499","mexK","ARO:3003693","mexK is the inner membrane resistance-nodulation-cell division (RND) transporter in the MexJK multidrug efflux protein."]
["gene0513","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene0518","tlrC","ARO:3002827","tlrC is an efflux pump found in Streptomyces fradiae and confers resistance to mycinamicin"]
["gene0579","smeS","ARO:3003067","smeS is the protein kinase sensor component of a two component signal transduction system that includes smeR"]
["gene0580","kdpE","ARO:3003841","kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding."]
["gene0622","oleC","ARO:3003748","oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion."]
["gene0636","mecC","ARO:3001209","A foreign PBP2a acquired by lateral gene transfer that able to perform peptidoglycan synthesis in the presence of beta-lactams."]
["gene0673","tlrC","ARO:3002827","tlrC is an efflux pump found in Streptomyces fradiae and confers resistance to mycinamicin"]
["gene0675","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene0679","vanHF","ARO:3002945","vanHF is a vanH variant in the vanF gene cluster"]
["gene0699","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene0712","mefE","ARO:3000614","mefE is a proton motive efflux pump in Streptococcus pneumoniae that confers resistance to macrolides. It is found on the same operon as mefA and the ABC-efflux pump mel."]
["gene0720","fyuA","ARO:3003833","fyuA is a pesticin receptor that is found in E.coli. The fyuA gene encodes the outer membrane receptor for the siderophore yersiniabactin (Ybt) and the hemR gene."]
["gene0731","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance"]
["gene0751","lmrC","ARO:3002881","lmrC is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrD"]
["gene0752","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance"]
["gene0755","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene0765","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene0773","mexQ","ARO:3003699","MexQ is the inner membrane transporter of the multidrug efflux pump MexPQ-OpmE."]
["gene0774","cmeB","ARO:3000784","CmeB is the inner membrane transporter the CmeABC multidrug efflux complex."]
["gene0775","mdtA","ARO:3000792","MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC."]
["gene0781","ramA","ARO:3000823","RamA (resistance antibiotic multiple) is a positive regulator of AcrAB-TolC and leads to high level multidrug resistance in Klebsiella pneumoniae"]
["gene0783","Klebsiella pneumoniae ramR mutants","ARO:3003380","RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB"]
["gene0795","facT","ARO:3001313","Efflux protein facT confers resistance to factumycin. The gene has been heterologously expressed in S. coelicolor and its function was confirmed (Thaker et al. Med. Chem. Commun. 2012"]
["gene0815","Enterococcus faecium liaR mutant conferring daptomycin resistance","ARO:3003078","liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance."]
["gene0837","lmrC","ARO:3002881","lmrC is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrD"]
["gene0838","mexE","ARO:3000803","MexE is the membrane fusion protein of the MexEF-OprN multidrug efflux complex."]
["gene0850","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene0910","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene0915","carA","ARO:3002817","carA is an ABC transporter involved in macrolide resistance. It is found in Streptomyces thermotolerans"]
["gene0918","golS","ARO:3000504","GolS is a regulator activated by the presence of gold"]
["gene0925","rosA","ARO:3003048","rosA is an efflux pump in Yersinia that confers resistance to cationic antimicrobial peptides such as polymyxin B"]
["gene0927","rosB","ARO:3003049","rosB is a potassium antiporter in Yersinia that confers resistance to cationic antimicrobial peptides such as polymyxin B"]
["gene0943","Klebsiella pneumoniae acrR mutant resulting in high level antibiotic resistance","ARO:3003373","AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance."]
["gene0944","acrA","ARO:3000207","Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrA represents the periplasmic portion of the transport protein."]
["gene0945","acrB","ARO:3000216","Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter."]
["gene0949","vatF","ARO:3003744","vatF is a streptogramin A acetyl transferase gene isolated from the chromosome of Yersinia enterocolitica."]
["gene0966","efrA","ARO:3003948","efrA is a part of the EfrAB efflux pump"]
["gene0985","sav1866","ARO:3000489","Sav1866 is a multidrug efflux pump in the Gram-positive Staphylococcus aureus. It is a homolog of the human ABC transporter Mdr1 and pumps out toxic compounds including verapamil"]
["gene0986","novA","ARO:3002522","A type III ABC transporter"]
["gene0987","sav1866","ARO:3000489","Sav1866 is a multidrug efflux pump in the Gram-positive Staphylococcus aureus. It is a homolog of the human ABC transporter Mdr1 and pumps out toxic compounds including verapamil"]
["gene1027","hp1181","ARO:3003964","hp1181 is a translocase that is part of the MFS efflux pump family. It is found in H. pylori and has role in the active efflux of antibiotics."]
["gene1072","baeS","ARO:3000829","BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity"]
["gene1073","baeR","ARO:3000828","BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes."]
["gene1089","mdtG","ARO:3001329","Efflux protien mdtG."]
["gene1092","D-Ala-D-Ala ligase","ARO:3003970","Non-van ligases that synthesize D-Ala-D-Ala"]
["gene1107","lmrD","ARO:3002882","lmrD is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrC"]
["gene1108","efrB","ARO:3003949","efrB is a part of the EfrAB efflux pump"]
["gene1124","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene1125","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance"]
["gene1129","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene1138","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene1146","Escherichia coli ompF mutants","ARO:3003390","Mutant forms of the Escherichia coli outer membrane porin OmpF result in reduced permeability to antibiotics."]
["gene1161","Enterococcus faecium liaR mutant conferring daptomycin resistance","ARO:3003078","liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance."]
["gene1175","patA","ARO:3000024","PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance."]
["gene1181","tet34","ARO:3002870","tet34 causes the activation of Mg2+-dependent purine nucleotide synthesis"]
["gene1211","cmlv","ARO:3002700","cmlv is a chromosome-encoded chloramphenicol phoshotransferase that is found in Streptomyces venezuelae"]
["gene1221","lmrC","ARO:3002881","lmrC is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrD"]
["gene1239","LpxA","ARO:3003573","The LpxA gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane"]
["gene1273","tlrC","ARO:3002827","tlrC is an efflux pump found in Streptomyces fradiae and confers resistance to mycinamicin"]
["gene1276","Streptococcus pneumoniae PBP1a conferring resistance to amoxicillin","ARO:3003041","PBP1a is a penicillin-binding protein found in Streptococcus pneumoniae"]
["gene1312","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance"]
["gene1313","oleC","ARO:3003748","oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion."]
["gene1354","LpxC","ARO:3003574","The LpxC gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane"]
["gene1359","vanN","ARO:3002912","VanN is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser"]
["gene1369","Neisseria meningititis PBP2 conferring resistance to beta-lactam","ARO:3003937","Point mutation in Neisseria meningititis PBP2 (penA) decreases affinity between beta-lactam antibiotic molecule and PBP2"]
["gene1378","leuO","ARO:3003843","leuO"]
["gene1396","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene1410","arlS","ARO:3000839","ArlS is a protein histidine kinase that phosphorylates ArlR"]
["gene1417","Erm(34)","ARO:3000600","ErmD confers MLSb phenotype."]
["gene1420","dfrA3","ARO:3003105","dfrA3 is an integron-encoded dihydrofolate reductase found in Escherichia coli"]
["gene1460","vanRE","ARO:3002924","vanRE is a vanR variant found in the vanE gene cluster"]
["gene1463","baeS","ARO:3000829","BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity"]
["gene1464","baeR","ARO:3000828","BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes."]
["gene1466","robA","ARO:3000825","robA is a positive regulator for the acrAB efflux genes"]
["gene1471","oleB","ARO:3003036","oleB is an ABC transporter in Streptomyces antibioticus and is involved in oleandomycin secretion"]
["gene1487","tetW","ARO:3000194","TetW is a ribosomal protection protein. It is associated with both conjugative and non conjugative DNA and has been found strains of C. difficile."]
["gene1553","mdtM","ARO:3001214","Multidrug resistance protein MdtM"]
["gene1554","mdtM","ARO:3001214","Multidrug resistance protein MdtM"]
["gene1561","mdtE","ARO:3000795","MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA."]
["gene1567","FosA5","ARO:3003209","fosA5 is a fosfomycin resistance gene isolated from clinical strain of Escherichia coli E265. It is susceptible to amikacin"]
["gene1568","mexT","ARO:3000814","MexT is a LysR-type transcriptional activator that positively regulates the expression of MexEF-OprN and OprD."]
["gene1586","qacH","ARO:3003836","qacH is a subunit of the qac multidrug efflux pump in Vibrio cholerae"]
["gene1587","qacH","ARO:3003836","qacH is a subunit of the qac multidrug efflux pump in Vibrio cholerae"]
["gene1591","farA","ARO:3003961","farA is the membrane fusion protein that is part of the farAB efflux pump."]
["gene1592","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene1604","baeS","ARO:3000829","BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity"]
["gene1605","Pseudomonas mutant PhoP conferring resistance to colistin","ARO:3003895","Mutations in Pseudomonas aeruginosa PhoP of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin."]
["gene1608","mexV","ARO:3003030","MexV is the membrane fusion protein of the MexVW-OprM multidrug efflux complex."]
["gene1609","oqxB","ARO:3003923","RND efflux pump conferring resistance to fluoroquinolone"]
["gene1647","lmrD","ARO:3002882","lmrD is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrC"]
["gene1720","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene1801","qacH","ARO:3003836","qacH is a subunit of the qac multidrug efflux pump in Vibrio cholerae"]
["gene1811","sav1866","ARO:3000489","Sav1866 is a multidrug efflux pump in the Gram-positive Staphylococcus aureus. It is a homolog of the human ABC transporter Mdr1 and pumps out toxic compounds including verapamil"]
["gene1867","carA","ARO:3002817","carA is an ABC transporter involved in macrolide resistance. It is found in Streptomyces thermotolerans"]
["gene1869","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene1875","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene1883","cpxR","ARO:3000831","CpxR is a regulator that promotes acrD expression when phosphorylated by a cascade involving CpxA"]
["gene1902","mexT","ARO:3000814","MexT is a LysR-type transcriptional activator that positively regulates the expression of MexEF-OprN and OprD."]
["gene1906","Escherichia coli soxR mutants","ARO:3003381","SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps."]
["gene1907","Salmonella serovars soxS mutants","ARO:3003383","SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability."]
["gene1914","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene1924","Escherichia coli soxS mutant","ARO:3003511","SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability."]
["gene1926","fyuA","ARO:3003833","fyuA is a pesticin receptor that is found in E.coli. The fyuA gene encodes the outer membrane receptor for the siderophore yersiniabactin (Ybt) and the hemR gene."]
["gene1956","lmrD","ARO:3002882","lmrD is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrC"]
["gene1991","evgS","ARO:3000833","EvgS is a sensor protein that phosphorylates the regulatory protein EvgA."]
["gene1992","vanSN","ARO:3002940","vanSN is a vanS variant found in the vanN gene cluster"]
["gene2015","Staphylococcus aureus rpoC conferring resistance to daptomycin","ARO:3003291","Point mutations that occurs in Staphylococcus aureus rpoC resulting in resistance to daptomycin"]
["gene2016","Escherichia coli rpoB mutants conferring resistance to rifampicin","ARO:3003288","Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin"]
["gene2023","Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa","ARO:3003370","Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Enacyloxin IIa"]
["gene2150","aminocoumarin resistant cysB","ARO:3003840","Positive regulator of gene expression in the cysteine regulon. cysB mutants confer resistance to novobiocin"]
["gene2161","aminocoumarin resistant cysB","ARO:3003840","Positive regulator of gene expression in the cysteine regulon. cysB mutants confer resistance to novobiocin"]
["gene2183","cpxR","ARO:3000831","CpxR is a regulator that promotes acrD expression when phosphorylated by a cascade involving CpxA"]
["gene2184","cpxA","ARO:3000830","CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR"]
["gene2196","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A"]
["gene2224","otrA","ARO:3002891","otrA is an oxytetracycline resistance ribosomal protection protein found in Streptomyces rimosus"]
["gene2228","vanRF","ARO:3002925","vanRF is a vanR variant found in the vanF gene cluster"]
["gene2247","mdtD","ARO:3001330","Efflux pump mdtD"]
["gene2252","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene2262","Mycobacterium tuberculosis gidB mutation conferring resistance to streptomycin","ARO:3003470","Specific mutations that occurs on Mycobacterium tuberculosis gidB causing it to be streptomycin resistant"]
["gene2280","sav1866","ARO:3000489","Sav1866 is a multidrug efflux pump in the Gram-positive Staphylococcus aureus. It is a homolog of the human ABC transporter Mdr1 and pumps out toxic compounds including verapamil"]
["gene2291","mexT","ARO:3000814","MexT is a LysR-type transcriptional activator that positively regulates the expression of MexEF-OprN and OprD."]
["gene2292","mdtL","ARO:3001215","Multidrug resistance protein MdtL"]
["gene2302","Salmonella serovars gyrB conferring resistance to fluoroquinolone","ARO:3003307","Point mutation in Salmonella serovars resulting in fluoroquinolone resistance"]
["gene2303","Escherichia coli gyrB conferring resistance to aminocoumarin","ARO:3003303","Point mutation in Escherichia coli resulting in aminocoumarin resistance"]
["gene2327","emrD","ARO:3000309","EmrD is a multidrug transporter from the Major Facilitator Superfamily (MFS) primarily found in Escherichia coli. EmrD couples efflux of amphipathic compounds with proton import across the plasma membrane."]
["gene2338","Escherichia coli mutant UhpT conferring resistance to fosfomycin","ARO:3003890","Mutations to the active importer UhpT"]
["gene2339","Escherichia coli mutant UhpT conferring resistance to fosfomycin","ARO:3003890","Mutations to the active importer UhpT"]
["gene2350","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene2372","smeC","ARO:3003053","smeC is an outer membrane multidrug efflux protein of the smeABC complex in Stenotrophomonas maltophilia"]
["gene2373","acrB","ARO:3000216","Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter."]
["gene2374","acrA","ARO:3000207","Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrA represents the periplasmic portion of the transport protein."]
["gene2379","otrB","ARO:3002892","otrB is a tetracycline resistance efflux pump found in Streptomyces rimosus"]
["gene2390","Salmonella serovars soxS mutants","ARO:3003383","SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability."]
["gene2425","mfd","ARO:3003844","mfd dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. The Mfd (mutation frequency decline) protein"]
["gene2441","oleC","ARO:3003748","oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion."]
["gene2496","ceoA","ARO:3003009","ceoA is a periplasmic linker subunit of the CeoAB-OpcM efflux pump"]
["gene2499","Streptomyces cinnamoneus EF-Tu mutants conferring resistance to elfamycin","ARO:3003359","Sequence variants of Streptomyces cinnamoneus elongation factor Tu that confer resistance to elfamycin antibiotics."]
["gene2507","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance"]
["gene2508","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene2521","tlrC","ARO:3002827","tlrC is an efflux pump found in Streptomyces fradiae and confers resistance to mycinamicin"]
["gene2526","vanHO","ARO:3002948","vanHO is a vanH variant in the vanO gene cluster"]
["gene2549","lmrC","ARO:3002881","lmrC is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrD"]
["gene2580","NmcR","ARO:3003665","NmcR is a homolog of the LysR regulator found in Enterobacter cloacae that contribute to the regulation of NmcA beta-lactamase"]
["gene2600","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A"]
["gene2601","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene2608","PmrF","ARO:3003578","PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A"]
["gene2627","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene2632","patA","ARO:3000024","PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance."]
["gene2641","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene2642","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene2648","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A"]
["gene2674","Enterococcus faecium liaR mutant conferring daptomycin resistance","ARO:3003078","liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance."]
["gene2688","vanRI","ARO:3003728","VanRI is the regulatory transcriptional activator in the VanSR regulator within the VanI glycopeptide resistance gene cluster."]
["gene2689","cpxA","ARO:3000830","CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR"]
["gene2699","Streptococcus pneumoniae PBP1a conferring resistance to amoxicillin","ARO:3003041","PBP1a is a penicillin-binding protein found in Streptococcus pneumoniae"]
["gene2723","patA","ARO:3000024","PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance."]
["gene2727","CRP","ARO:3000518","CRP is a global regulator that represses MdtEF multidrug efflux pump expression."]
["gene2732","tlrC","ARO:3002827","tlrC is an efflux pump found in Streptomyces fradiae and confers resistance to mycinamicin"]
["gene2743","Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin","ARO:3003395","Ribosomal protein S12 stabilizes the highly conserved"]
["gene2745","tetB(P)","ARO:3000195","TetB(P) is a tetracycline ribosomal protection protein found on the same operon as tetA(P)"]
["gene2746","Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa","ARO:3003370","Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Enacyloxin IIa"]
["gene2747","Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa","ARO:3003370","Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Enacyloxin IIa"]
["gene2751","rpsJ","ARO:3003930","rpsJ is a tetracycline resistance protein identified in Neisseria gonorrhoeae. Tetracycline resistance is conferred by binding to the ribosome as a 30S ribosomal protection protein."]
["gene2780","golS","ARO:3000504","GolS is a regulator activated by the presence of gold"]
["gene2802","acrF","ARO:3000502","AcrF is a inner membrane transporter"]
["gene2803","acrE","ARO:3000499","AcrE is a membrane fusion protein"]
["gene2805","acrS","ARO:3000656","AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux."]
["gene2829","mexE","ARO:3000803","MexE is the membrane fusion protein of the MexEF-OprN multidrug efflux complex."]
["gene2854","evgS","ARO:3000833","EvgS is a sensor protein that phosphorylates the regulatory protein EvgA."]
["gene2863","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene2869","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene2876","Escherichia coli mutant murA conferring resistance to fosfomycin","ARO:3003775","murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations such as Asp369Asn and Leu370Ile confers fosfomycin resistance. Extensive evidence has shown the significance of C115 mutations in conferring fosfomycin resistance since this residue represents a primary binding site for the antibiotic across many species."]
["gene2891","Escherichia coli sulfonamide resistant mutant folP","ARO:3003386","Point mutations in Escherichia coli dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis"]
["gene2988","oleC","ARO:3003748","oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion."]
["gene2994","patA","ARO:3000024","PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance."]
["gene3022","evgS","ARO:3000833","EvgS is a sensor protein that phosphorylates the regulatory protein EvgA."]
["gene3023","evgA","ARO:3000832","EvgA"]
["gene3085","bacA","ARO:3002986","bacA is a gene that recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin"]
["gene3101","tolC","ARO:3000237","TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex."]
["gene3106","Salmonella serovars parE conferring resistance to fluoroquinolones","ARO:3003317","Point mutation in Salmonella serovars parE resulting in fluoroquinolones resistance"]
["gene3109","PmrB","ARO:3003583","Histidine protein kinase sensor Lipid A modification gene, part of a two-component system involved in polymyxin resistance that senses high extracellular Fe(2+)"]
["gene3110","PmrA","ARO:3003582","Response regulator for Lipid A modification genes, two-component system involved in polymyxin resistance that senses high extracellular Fe(2+)"]
["gene3112","robA","ARO:3000825","robA is a positive regulator for the acrAB efflux genes"]
["gene3113","Escherichia coli parC conferring resistance to fluoroquinolone","ARO:3003308","Point mutation in Escherichia coli parC resulting in fluoroquinolone resistance"]
["gene3156","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene3165","Enterococcus faecium liaR mutant conferring daptomycin resistance","ARO:3003078","liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance."]
["gene3179","Pseudomonas aeruginosa oprD conferring resistance to imipenem","ARO:3003686","oprD is an outer membrane porin which facilitates the uptake of basic amino acids and imipenem in Pseudomonas aeruginosa."]
["gene3188","NmcR","ARO:3003665","NmcR is a homolog of the LysR regulator found in Enterobacter cloacae that contribute to the regulation of NmcA beta-lactamase"]
["gene3224","emrB","ARO:3000074","emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP)"]
["gene3225","mexT","ARO:3000814","MexT is a LysR-type transcriptional activator that positively regulates the expression of MexEF-OprN and OprD."]
["gene3240","mdtP","ARO:3003550","Multidrug resistance efflux pump. Could be involved in resistance to puromycin"]
["gene3242","mdtO","ARO:3003549","Multidrug resistance efflux pump. Could be involved in resistance to puromycin"]
["gene3243","mdtN","ARO:3003548","Multidrug resistance efflux pump. Could be involved in resistance to puromycin"]
["gene3290","novA","ARO:3002522","A type III ABC transporter"]
["gene3316","dfrE","ARO:3002875","dfrE is a chromosome-encoded dihydrofolate reductase found in Enterococcus faecalis"]
["gene3385","NmcR","ARO:3003665","NmcR is a homolog of the LysR regulator found in Enterobacter cloacae that contribute to the regulation of NmcA beta-lactamase"]
["gene3404","novA","ARO:3002522","A type III ABC transporter"]
["gene3426","evgS","ARO:3000833","EvgS is a sensor protein that phosphorylates the regulatory protein EvgA."]
["gene3455","mdtD","ARO:3001330","Efflux pump mdtD"]
["gene3457","mexR","ARO:3000506","MexR is the repressor of the MexRAB-OprM operon. Mutant forms of mexR result in up-regulation of efflux protein MexAB-OprM."]
["gene3465","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene3478","lmrC","ARO:3002881","lmrC is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrD"]
["gene3534","aminocoumarin resistant alaS","ARO:3003830","alanyl-tRNA synthetase conferring resistance to novobiocin in Escherichia coli"]
["gene3549","emrB","ARO:3000074","emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP)"]
["gene3550","emrB","ARO:3000074","emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP)"]
["gene3551","emrA","ARO:3000027","EmrA is a membrane fusion protein"]
["gene3553","emrR","ARO:3000516","EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression."]
["gene3559","efrA","ARO:3003948","efrA is a part of the EfrAB efflux pump"]
["gene3571","H-NS","ARO:3000676","H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE"]
["gene3577","NmcR","ARO:3003665","NmcR is a homolog of the LysR regulator found in Enterobacter cloacae that contribute to the regulation of NmcA beta-lactamase"]
["gene3598","oleC","ARO:3003748","oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion."]
["gene3606","oqxB","ARO:3003923","RND efflux pump conferring resistance to fluoroquinolone"]
["gene3607","oqxA","ARO:3003922","RND efflux pump conferring resistance to fluoroquinolone"]
["gene3608","robA","ARO:3000825","robA is a positive regulator for the acrAB efflux genes"]
["gene3678","tetB(P)","ARO:3000195","TetB(P) is a tetracycline ribosomal protection protein found on the same operon as tetA(P)"]
["gene3696","evgS","ARO:3000833","EvgS is a sensor protein that phosphorylates the regulatory protein EvgA."]
["gene3731","cfrA","ARO:3003441","Cfr enzyme adds an additional methyl group at position 8 of A2503 in 23S rRNA"]
["gene3778","acrD","ARO:3000491","AcrD is an aminoglycoside efflux pump expressed in E. coli. Its expression can be induced by indole"]
["gene3815","lmrD","ARO:3002882","lmrD is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrC"]
["gene3864","NmcR","ARO:3003665","NmcR is a homolog of the LysR regulator found in Enterobacter cloacae that contribute to the regulation of NmcA beta-lactamase"]
["gene3905","efrA","ARO:3003948","efrA is a part of the EfrAB efflux pump"]
["gene3923","patB","ARO:3000025","PatB is an ABC transporter of Streptococcus pneumoniae that interacts with PatA to confer fluoroquinolone resistance.."]
["gene3968","Escherichia coli mutant GlpT conferring resistance to fosfomycin","ARO:3003889","Mutations to the active importer GlpT"]
["gene3975","Salmonella enterica gyrA conferring resistance to fluoroquinolones","ARO:3003926","Point mutations in Salmonella gyrA that confer resistance to Nalidixic acid"]
["gene3976","evgS","ARO:3000833","EvgS is a sensor protein that phosphorylates the regulatory protein EvgA."]
["gene3980","Enterobacter aerogenes omp36 mutants","ARO:3003385","Mutant forms of the porin Omp36 result in reduced permeability to antibiotics."]
["gene3984","YojI","ARO:3003952","YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules.  The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI."]
["gene3996","SRT-2","ARO:3002494","SRT-2"]
["gene4004","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance"]
["gene4030","fyuA","ARO:3003833","fyuA is a pesticin receptor that is found in E.coli. The fyuA gene encodes the outer membrane receptor for the siderophore yersiniabactin (Ybt) and the hemR gene."]
["gene4036","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A"]
["gene4050","mdtP","ARO:3003550","Multidrug resistance efflux pump. Could be involved in resistance to puromycin"]
["gene4061","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene4075","Enterococcus faecium adeC","ARO:3000776","AdeC is the outer membrane factor of the AdeABC multidrug efflux complex. It can be replaced by other outer membrane channels"]
["gene4119","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance"]
["gene4123","baeR","ARO:3000828","BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes."]
["gene4124","baeS","ARO:3000829","BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity"]
["gene4125","baeS","ARO:3000829","BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity"]
["gene4126","mdtD","ARO:3001330","Efflux pump mdtD"]
["gene4127","mdtC","ARO:3000794","MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB"]
["gene4128","mdtB","ARO:3000793","MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex."]
["gene4129","mdtB","ARO:3000793","MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex."]
["gene4130","mdtA","ARO:3000792","MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC."]
["gene4135","Pseudomonas mutant PhoP conferring resistance to colistin","ARO:3003895","Mutations in Pseudomonas aeruginosa PhoP of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin."]
["gene4169","PmrE","ARO:3003577","PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A"]
["gene4172","arnA","ARO:3002985","arnA modifies lipid A with 4-amino-4-deoxy-L-arabinose (Ara4N) which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. arnA is found in E. coli and P. aeruginosa."]
["gene4174","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene4181","PmrF","ARO:3003578","PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A"]
["gene4196","tetT","ARO:3000193","Tet(T) is a ribosomal protection protein of streptococci. It is similar to Tet(Q)."]
["gene4225","mdtK","ARO:3001327","A multidrug and toxic compound extrusions (MATE) transporter conferring resistance to norfloxacin"]
["gene4226","mdtK","ARO:3001327","A multidrug and toxic compound extrusions (MATE) transporter conferring resistance to norfloxacin"]
["gene4236","aminocoumarin resistant cysB","ARO:3003840","Positive regulator of gene expression in the cysteine regulon. cysB mutants confer resistance to novobiocin"]
["gene4243","Enterobacter aerogenes omp36 mutants","ARO:3003385","Mutant forms of the porin Omp36 result in reduced permeability to antibiotics."]
["gene4261","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene4262","sdiA","ARO:3000826","SdiA is a cell division regulator that is also a positive regulator of AcrAB only when it's expressed from a plasmid. When the sdiA gene is on the chromosome"]
["gene4264","Enterococcus faecium liaR mutant conferring daptomycin resistance","ARO:3003078","liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance."]
["gene4280","mdtD","ARO:3001330","Efflux pump mdtD"]
["gene4286","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A"]
["gene4308","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance"]
["gene4340","otrB","ARO:3002892","otrB is a tetracycline resistance efflux pump found in Streptomyces rimosus"]
["gene4348","Neisseria meningititis PBP2 conferring resistance to beta-lactam","ARO:3003937","Point mutation in Neisseria meningititis PBP2 (penA) decreases affinity between beta-lactam antibiotic molecule and PBP2"]
["gene4385","vanTG","ARO:3002972","vanTG is a vanT variant found in the vanG gene cluster"]
["gene4412","oleC","ARO:3003748","oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion."]
["gene4413","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene4478","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene4482","Enterococcus faecium liaR mutant conferring daptomycin resistance","ARO:3003078","liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance."]
["gene4499","H-NS","ARO:3000676","H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE"]
["gene4509","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene4511","novA","ARO:3002522","A type III ABC transporter"]
["gene4544","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene4552","rifampin phosphotransferase","ARO:3000444","The enzymatic inactivation of rifampin by phosphorylation at the 21-OH position."]
["gene4562","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene4569","TriB","ARO:3003680","TriB is a membrane protein that is fused to TriA and both are required for the triclosan efflux pump function of TriABC-OpmH in P. aeruginosa."]
["gene4570","mexK","ARO:3003693","mexK is the inner membrane resistance-nodulation-cell division (RND) transporter in the MexJK multidrug efflux protein."]
["gene4571","mexK","ARO:3003693","mexK is the inner membrane resistance-nodulation-cell division (RND) transporter in the MexJK multidrug efflux protein."]
["gene4576","lmrD","ARO:3002882","lmrD is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrC"]
["gene4593","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A"]
["gene4598","iri","ARO:3002884","iri is a monooxygenase that confers resistance to rifampin found in Rhodococcus equi"]
["gene4620","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene4622","tlrC","ARO:3002827","tlrC is an efflux pump found in Streptomyces fradiae and confers resistance to mycinamicin"]
["gene4632","efrA","ARO:3003948","efrA is a part of the EfrAB efflux pump"]
["gene4635","mdtM","ARO:3001214","Multidrug resistance protein MdtM"]
["gene4646","novA","ARO:3002522","A type III ABC transporter"]
["gene4663","adeS","ARO:3000549","AdeS is a sensor kinase in the AdeRS regulatory system of AdeABC. It is essential for AdeABC expression."]
["gene4664","adeR","ARO:3000553","AdeR is a positive regulator of AdeABC efflux system. AdeR inactivation leads to susceptibility to aminoglycoside antibiotics."]
["gene4667","adeB","ARO:3000775","AdeB is the multidrug transporter of the adeABC efflux system."]
["gene4668","adeB","ARO:3000775","AdeB is the multidrug transporter of the adeABC efflux system."]
["gene4699","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene4719","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance"]
["gene4720","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene4736","AIM-1","ARO:3000853","AIM-1 is an Ambler class B beta-lactamase that hydrolyzes most beta-lactams except aztreonam and ceftazidime. It was isolated from Pseudomonas aeruginosa."]
["gene4748","hmrM","ARO:3003953","hmrM is a multidrug efflux pump belonging to the MATE family and functions as a  Na+/drug antiporter."]
["gene4751","floR","ARO:3002705","floR is a plasmid or chromosome-encoded chloramphenicol exporter that is found in Bordetella bronchiseptica"]
["gene4753","cmlv","ARO:3002700","cmlv is a chromosome-encoded chloramphenicol phoshotransferase that is found in Streptomyces venezuelae"]
["gene4755","tetD","ARO:3000168","TetD is a tetracycline efflux pump found exclusively in Gram-negative bacteria."]
["gene4767","mdtN","ARO:3003548","Multidrug resistance efflux pump. Could be involved in resistance to puromycin"]
["gene4820","robA","ARO:3000825","robA is a positive regulator for the acrAB efflux genes"]
["gene4834","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC."]
["gene4859","fyuA","ARO:3003833","fyuA is a pesticin receptor that is found in E.coli. The fyuA gene encodes the outer membrane receptor for the siderophore yersiniabactin (Ybt) and the hemR gene."]
["gene4874","oleC","ARO:3003748","oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion."]
["gene4886","efrA","ARO:3003948","efrA is a part of the EfrAB efflux pump"]
["gene4900","qepA","ARO:3000448","QepA is a plasmid-mediated fluoroquinolone efflux pump found in E. coli. It is regulated by sox genes"]
["gene4924","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A"]
["gene4931","msrE","ARO:3003109","MsrE is an ABC-efflux pump expressed to Klebsiella pneumoniae that confers resistance to erythromycin and streptogramin B antibiotics. It is associated with plasmid DNA."]
["gene4967","Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid","ARO:3003392","katG is a catalase-peroxidase that catalyzes the activation of isoniazid. Isoniazid inhibits mycolic acid synthesis"]
["gene4971","mecC","ARO:3001209","A foreign PBP2a acquired by lateral gene transfer that able to perform peptidoglycan synthesis in the presence of beta-lactams."]
["gene4984","baeR","ARO:3000828","BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes."]
["gene4986","baeS","ARO:3000829","BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity"]
["gene4992","patA","ARO:3000024","PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance."]
["gene4995","novA","ARO:3002522","A type III ABC transporter"]
["gene5026","Mycobacterium tuberculosis kasA mutant conferring resistance to isoniazid","ARO:3003463","Specific mutations on the Mycobacterium tuberculosis kasA gene resulting in lowered affinity of isoniazid"]
["gene5028","farA","ARO:3003961","farA is the membrane fusion protein that is part of the farAB efflux pump."]
["gene5042","oleC","ARO:3003748","oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion."]
["gene5052","tet39","ARO:3000566","Tet39 is a tetracycline efflux pump found in Gram-negative bacteria"]
["gene5056","adeN","ARO:3000559","AdeN is a repressor of AdeIJK"]
["gene5080","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance"]
["gene5088","Escherichia coli mutant GlpT conferring resistance to fosfomycin","ARO:3003889","Mutations to the active importer GlpT"]
["gene5166","sav1866","ARO:3000489","Sav1866 is a multidrug efflux pump in the Gram-positive Staphylococcus aureus. It is a homolog of the human ABC transporter Mdr1 and pumps out toxic compounds including verapamil"]
["gene5179","AAC(6')-Iy","ARO:3002569","AAC(6')-Iy is a chromosomal-encoded aminoglycoside acetyltransferase in S. enteritidis and S. enterica. Regulatory mutation required to increase expression of this chromosomally-encoded gene for resistance. In the specific system"]
["gene5195","vanHF","ARO:3002945","vanHF is a vanH variant in the vanF gene cluster"]
["gene5198","cmlv","ARO:3002700","cmlv is a chromosome-encoded chloramphenicol phoshotransferase that is found in Streptomyces venezuelae"]
["gene5201","Escherichia coli marR mutant conferring antibiotic resistance","ARO:3003378","MarR is a repressor of the mar operon marRAB"]
["gene5202","marA","ARO:3000263","In the presence of antibiotic stress"]
["gene5207","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance"]
["gene5209","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump."]
["gene5224","SHV-1","ARO:3001059","SHV-1 is a broad-spectrum beta-lactamase found in Klebsiella spp."]
["gene5232","Escherichia coli soxS mutant","ARO:3003511","SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability."]
["gene5264","aminocoumarin resistant cysB","ARO:3003840","Positive regulator of gene expression in the cysteine regulon. cysB mutants confer resistance to novobiocin"]
["gene5274","qacH","ARO:3003836","qacH is a subunit of the qac multidrug efflux pump in Vibrio cholerae"]
["gene5294","cpxR","ARO:3000831","CpxR is a regulator that promotes acrD expression when phosphorylated by a cascade involving CpxA"]
["gene5330","vanRI","ARO:3003728","VanRI is the regulatory transcriptional activator in the VanSR regulator within the VanI glycopeptide resistance gene cluster."]
["gene5334","cpxA","ARO:3000830","CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR"]
["gene5362","patA","ARO:3000024","PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance."]
["gene5371","emrB","ARO:3000074","emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP)"]
["gene5372","farA","ARO:3003961","farA is the membrane fusion protein that is part of the farAB efflux pump."]
["gene5404","vanHF","ARO:3002945","vanHF is a vanH variant in the vanF gene cluster"]
["gene5408","Enterobacter aerogenes omp36 mutants","ARO:3003385","Mutant forms of the porin Omp36 result in reduced permeability to antibiotics."]
["gene5409","Enterobacter aerogenes omp36 mutants","ARO:3003385","Mutant forms of the porin Omp36 result in reduced permeability to antibiotics."]
["gene5423","sav1866","ARO:3000489","Sav1866 is a multidrug efflux pump in the Gram-positive Staphylococcus aureus. It is a homolog of the human ABC transporter Mdr1 and pumps out toxic compounds including verapamil"]
["gene5426","mexS","ARO:3000813","MexS is a suppressor of MexT"]
["gene5430","mexT","ARO:3000814","MexT is a LysR-type transcriptional activator that positively regulates the expression of MexEF-OprN and OprD."]
["gene5506","norB","ARO:3000421","NorB is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 30% similarity with NorB"]
["gene5584","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance"]
["gene5607","aminocoumarin resistant cysB","ARO:3003840","Positive regulator of gene expression in the cysteine regulon. cysB mutants confer resistance to novobiocin"]
["gene5608","aminocoumarin resistant cysB","ARO:3003840","Positive regulator of gene expression in the cysteine regulon. cysB mutants confer resistance to novobiocin"]
["gene5617","NmcR","ARO:3003665","NmcR is a homolog of the LysR regulator found in Enterobacter cloacae that contribute to the regulation of NmcA beta-lactamase"]
["gene5637","fyuA","ARO:3003833","fyuA is a pesticin receptor that is found in E.coli. The fyuA gene encodes the outer membrane receptor for the siderophore yersiniabactin (Ybt) and the hemR gene."]
["gene5662","patA","ARO:3000024","PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance."]
["gene5669","tlrC","ARO:3002827","tlrC is an efflux pump found in Streptomyces fradiae and confers resistance to mycinamicin"]
["gene5684","Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide","ARO:3003394","pncA is a pyrazinamidase/nicotinamidase. It catalyzes the activation of pyrazinamide. Some mutation within pncA are associated with loss of enzyme activity"]
["gene5766","aminocoumarin resistant cysB","ARO:3003840","Positive regulator of gene expression in the cysteine regulon. cysB mutants confer resistance to novobiocin"]

{"sheet":"Pathogen host interactions ","index":2,"n_rows":829,"n_cols":3,"rows_kept":829}
["Excel S2. Human disease-related systems of the K. pneumoniae NKU_KlebA1. Pathogen-host interactions (C)."]
["Gene ID","PHI ID","Function"]
["gene0021","PHI:2674","Regulators of systemic infection"]
["gene0022","PHI:4162","govern the expression of cps and of the loci implicated in lipid A remodeling"]
["gene0027","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene0035","PHI:6938;PHI:6989","Iron siderophore;Pyochelin biosynthesis protein"]
["gene0049","PHI:5572","nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase"]
["gene0051","PHI:2631","Glucokinase"]
["gene0054","PHI:3928","ABC-Type Ef?ux Pump"]
["gene0057","PHI:6483","DNA repair"]
["gene0064","PHI:3297","siderophore-mediated iron acquisition"]
["gene0065","PHI:3297","siderophore-mediated iron acquisition"]
["gene0067","PHI:3629","Possible dehydrogenase"]
["gene0070","PHI:3282","b-lactamase induction"]
["gene0078","PHI:6309","Glucose uptake protein"]
["gene0079","PHI:6309","Glucose uptake protein"]
["gene0085","PHI:724;PHI:730","Polyketide synthase"]
["gene0087","PHI:5271","3-ketoacyl-acyl carrier protein reductase"]
["gene0088","PHI:5280","DHN melanin biosynthesis"]
["gene0095","PHI:3723","endoribonucleases"]
["gene0114","PHI:3154","pathogenitcity related"]
["gene0117","PHI:3787","acyltransferases"]
["gene0122","PHI:2699","Synthesis of a cyclic glucan"]
["gene0123","PHI:2699","Synthesis of a cyclic glucan"]
["gene0124","PHI:5564","Glucans biosynthesis protein"]
["gene0133","PHI:5548","AphB and OhrR monitor redox-potential changes and respond with different kinetics"]
["gene0163","PHI:4917","1,4-benzoquinone oxidoreductase"]
["gene0221","PHI:2145","Succinate-semialdehyde dehydrogenase"]
["gene0224","PHI:5548","AphB and OhrR monitor redox-potential changes and respond with different kinetics"]
["gene0229","PHI:3914","encodes succinic semialdehyde dehydrogenase"]
["gene0233","PHI:3042","phosphodiesterases"]
["gene0239","PHI:5244","Transcriptional regulator of virulence"]
["gene0252","PHI:4160","outer membrane proteins"]
["gene0261","PHI:6913","ATP Binding Cassette Protein"]
["gene0267","PHI:4028","Alkanesulphonate -Binding Protein"]
["gene0271","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene0279","PHI:3257","Threonine deaminase"]
["gene0282","PHI:1605","transcription factor"]
["gene0283","PHI:2872","Outer membrane protein"]
["gene0284","PHI:6261","Aspartate aminotransferase"]
["gene0301","PHI:6913","ATP Binding Cassette Protein"]
["gene0305","PHI:2673","Regulators of systemic infection"]
["gene0306","PHI:3878","polynucleotide phosphorylase, an exoribonuclease involved in RNA processing and degradation"]
["gene0308","PHI:2624;PHI:6460","Pathogenicity island;Carboxyvinyltransferase"]
["gene0318","PHI:604","tetrathionate reductase"]
["gene0321","PHI:6447","Holliday junction DNA helicase"]
["gene0322","PHI:6447","Holliday junction DNA helicase"]
["gene0326","PHI:6497","Global Transcription Factor"]
["gene0328","PHI:6470","Thioredoxin reductase"]
["gene0329","PHI:6913","ATP Binding Cassette Protein"]
["gene0330","PHI:6913","ATP Binding Cassette Protein"]
["gene0333","PHI:4559","Type VI secretion systems (T6SSs) effectors"]
["gene0334","PHI:5335","T6SS5 Effector"]
["gene0335","PHI:6212","Adapter protein"]
["gene0336","PHI:6372","Cold shock protein"]
["gene0337","PHI:3928","ABC-Type Ef?ux Pump"]
["gene0338","PHI:3929","ABC-Type Ef?ux Pump"]
["gene0349","PHI:469","Alanine racemase"]
["gene0353","PHI:4633","Diguanylate cyclase"]
["gene0357","PHI:3928","ABC-Type Ef?ux Pump"]
["gene0362","PHI:6313","Potassium homeostasis and virulence"]
["gene0364","PHI:4198;PHI:4846","serves to repress GAS virulence factor-encoding genes;no data found"]
["gene0367","PHI:6321","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene0370","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene0371","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene0404","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene0405","PHI:3412","phosphate metabolism"]
["gene0428","PHI:4912","PEA transferases"]
["gene0429","PHI:4911","PEA transferases"]
["gene0431","PHI:6250","Outer membrane protein"]
["gene0437","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene0448","PHI:6510","RNA Helicase"]
["gene0451","PHI:5271","3-ketoacyl-acyl carrier protein reductase"]
["gene0458","PHI:1017;PHI:2067","multidrug resistance;ABC Transporter"]
["gene0464","PHI:5093","Phospholipases D"]
["gene0474","PHI:4910","PEA transferases"]
["gene0475","PHI:4497","lipopolysaccharide modification regulator"]
["gene0476","PHI:4497","lipopolysaccharide modification regulator"]
["gene0477","PHI:6883","Two-component system sensor histidine kinase"]
["gene0484","PHI:3126","argDgene encodes a predicted N-acetylornithine aminotransferase enzyme"]
["gene0491","PHI:3135","Part of the pyruvate - tricarboxylic acid cycle node"]
["gene0495","PHI:440","P-type ATPase transporter"]
["gene0496","PHI:2095","Ca2+ pump"]
["gene0513","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene0515","PHI:5422","Phase-variable DNA methyltransferase"]
["gene0518","PHI:1018;PHI:2042","MDR Transporter;multidrug resistance;protection from oxidative stress"]
["gene0520","PHI:1133","UDP-4-Galactose epimerase"]
["gene0522","PHI:6269","Galactokinase"]
["gene0540","PHI:3137","Periplasmic component of the Tol-Pal system, a multi-protein complex present in almost all Gram-negative bacteria which connects the cytoplasmic (or inner) membrane with the outer membrane."]
["gene0541","PHI:3472","Periplasm spanning protein"]
["gene0542","PHI:3472","Periplasm spanning protein"]
["gene0557","PHI:2960","Fumarate reductase"]
["gene0562","PHI:3627","Formamidopyrimidine-DNA-glycosylase"]
["gene0571","PHI:4730","no data found"]
["gene0575","PHI:4712","Transport of small molecules"]
["gene0577","PHI:6313","Potassium homeostasis and virulence"]
["gene0579","PHI:6313","Potassium homeostasis and virulence"]
["gene0580","PHI:6314","Potassium homeostasis and virulence"]
["gene0587","PHI:4887","global ferric uptake regulator"]
["gene0592","PHI:2521","Glutamate-tRNA sythetase"]
["gene0593","PHI:2521","Glutamate-tRNA sythetase"]
["gene0594","PHI:6308","Glucose uptake protein"]
["gene0595","PHI:5472","GlcN-6-phosphate deaminase"]
["gene0601","PHI:2964","Asparagine synthetase"]
["gene0609","PHI:7028","Aerobic ubiquinone-8 synthase"]
["gene0610","PHI:7028","Aerobic ubiquinone-8 synthase"]
["gene0613","PHI:3059","essential endoribonuclease"]
["gene0616","PHI:3782","acyltransferases"]
["gene0622","PHI:3928","ABC-Type Ef?ux Pump"]
["gene0626","PHI:5388","Virulence factor/non-fimbrial adhesin protein"]
["gene0636","PHI:6884","Penicillin-binding protein"]
["gene0646","PHI:6492","Lipase"]
["gene0647","PHI:2415","virulence;Translocate folded proteins"]
["gene0652","PHI:6372","Cold shock protein"]
["gene0660","PHI:2846","Thioredoxin reductase"]
["gene0661","PHI:3066","Rho GTPase activating proteins"]
["gene0675","PHI:6324","Cysteine protease"]
["gene0699","PHI:6324","Cysteine protease"]
["gene0701","PHI:5271","3-ketoacyl-acyl carrier protein reductase"]
["gene0706","PHI:6270","Proofreading thioesterase"]
["gene0708","PHI:6565;PHI:6652","Enterobactin and salmochelin;Isochorismatase"]
["gene0709","PHI:6938;PHI:6989","Iron siderophore;Pyochelin biosynthesis protein"]
["gene0714","PHI:6849","ABC transporter"]
["gene0715","PHI:3412","phosphate metabolism"]
["gene0716","PHI:2894","Peptide synthetase"]
["gene0719","PHI:4859","Catecholate siderophore esterases"]
["gene0720","PHI:6654","Iron-regulated outer membrane virulence protein"]
["gene0731","PHI:3928","ABC-Type Ef?ux Pump"]
["gene0734","PHI:59","Reductase"]
["gene0735","PHI:1099;PHI:1100;PHI:2269","Mannitol 2-dehydrogenase"]
["gene0743","PHI:3914","encodes succinic semialdehyde dehydrogenase"]
["gene0744","PHI:199","Alcohol oxidase"]
["gene0751","PHI:3928","ABC-Type Ef?ux Pump"]
["gene0752","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene0753","PHI:2143","minor extracellular protease-encoding gene"]
["gene0755","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene0759","PHI:3028","MocR family of transcriptional regulators"]
["gene0763","PHI:3412","phosphate metabolism"]
["gene0765","PHI:3412","phosphate metabolism"]
["gene0773","PHI:6449","Multidrug efflux pump"]
["gene0775","PHI:6386","Multidrug efflux protein"]
["gene0777","PHI:440","P-type ATPase transporter"]
["gene0778","PHI:440","P-type ATPase transporter"]
["gene0781","PHI:5370","Transcriptional regulator"]
["gene0792","PHI:5256","Sigma-54 interaction domaincontaining protein"]
["gene0797","PHI:4564","global transcriptional regulator of carbon catabolite repression"]
["gene0798","PHI:4564","global transcriptional regulator of carbon catabolite repression"]
["gene0835","PHI:6849","ABC transporter"]
["gene0837","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene0847","PHI:2672","Regulators of systemic infection"]
["gene0850","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene0853","PHI:6382","inositol-2-dehydrogenase"]
["gene0860","PHI:1594","transcription factor"]
["gene0867","PHI:3787","acyltransferases"]
["gene0878","PHI:2651","Cyclic amidohydrolase that hydrolyses 5-hydroxyisourate (5-HIU)"]
["gene0903","PHI:501","Phosphoribosylaminoimidazole carboxylase"]
["gene0904","PHI:196","Phosphoribosylaminoimidazole carboxylase"]
["gene0910","PHI:3928","ABC-Type Ef?ux Pump"]
["gene0913","PHI:2644","Redox activity"]
["gene0915","PHI:4975","Functional Type 1 Secretion System"]
["gene0920","PHI:5275","Copper homeostasis"]
["gene0929","PHI:4734","no data found"]
["gene0931","PHI:6472","heat shock protein 90 chaperone"]
["gene0944","PHI:6386","Multidrug efflux protein"]
["gene0945","PHI:6451","Acriflavine resistance protein"]
["gene0947","PHI:3819","represses the transcription and expression of T3SS genes at room temperature"]
["gene0949","PHI:3436","Streptolysin S biosynthesis protein"]
["gene0958","PHI:6308","Glucose uptake protein"]
["gene0966","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene0968","PHI:3646","cyclic-di-GMP-specific phosphodiesterase"]
["gene0969","PHI:4684","Global/motility Regulator"]
["gene0985","PHI:6913","ATP Binding Cassette Protein"]
["gene0987","PHI:6912","ATP Binding Cassette Protein"]
["gene0995","PHI:3074","Nucleoid-associated protein, is a basic DNA-binding protein involved in gene regulation"]
["gene0996","PHI:5466","Bacterial two component system, SrrAB, which is known to help S. aureussurvive in low oxygen"]
["gene0997","PHI:5466","Bacterial two component system, SrrAB, which is known to help S. aureussurvive in low oxygen"]
["gene0999","PHI:3004","Part of proteolytic complex"]
["gene1000","PHI:3040","proteolytic component"]
["gene1007","PHI:4147","CyoA, cytochrome O ubiquinol oxidase"]
["gene1028","PHI:3259","Cyclic di-GMP Effectors"]
["gene1037","PHI:419","Cell surface protein"]
["gene1043","PHI:3464","regulator"]
["gene1057","PHI:386","Thiol peroxidase"]
["gene1062","PHI:6903","Fructose-bisphosphate aldolase"]
["gene1071","PHI:6629","BCAA transporter"]
["gene1072","PHI:6115","sensor histidine kinase"]
["gene1073","PHI:5466","Bacterial two component system, SrrAB, which is known to help S. aureussurvive in low oxygen"]
["gene1101","PHI:4692","Putative carboxypeptidase"]
["gene1107","PHI:3412","phosphate metabolism"]
["gene1108","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene1124","PHI:1017;PHI:2067","multidrug resistance;ABC Transporter"]
["gene1125","PHI:3412","phosphate metabolism"]
["gene1129","PHI:3928","ABC-Type Ef?ux Pump"]
["gene1138","PHI:3928","ABC-Type Ef?ux Pump"]
["gene1146","PHI:2872","Outer membrane protein"]
["gene1161","PHI:4690","Orphan response regulator"]
["gene1168","PHI:6520","Effector (plant avirulence determinant)"]
["gene1174","PHI:3914","encodes succinic semialdehyde dehydrogenase"]
["gene1175","PHI:5029","GABA transaminases"]
["gene1208","PHI:2975","Effector"]
["gene1212","PHI:5548","AphB and OhrR monitor redox-potential changes and respond with different kinetics"]
["gene1221","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene1239","PHI:3785","acyltransferases"]
["gene1241","PHI:3784","acyltransferases"]
["gene1259","PHI:6358","Protease"]
["gene1267","PHI:286","Chloride Channel"]
["gene1273","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene1274","PHI:6373","ferrichrome receptor"]
["gene1282","PHI:6859","Type II secretion system protein"]
["gene1284","PHI:6493","Type II secretion (T2S) system that is responsible for secretion of LipA"]
["gene1285","PHI:6363","Twitching motility"]
["gene1297","PHI:702","Required for philus assembly and CT secretion"]
["gene1298","PHI:1579","transcription factor"]
["gene1301","PHI:6508","Response Regulator"]
["gene1307","PHI:2257","Pantothenate- beta -alanine ligase"]
["gene1308","PHI:3968","Aspartate alpha-decarboxylase"]
["gene1312","PHI:1017;PHI:2067","multidrug resistance;ABC Transporter"]
["gene1313","PHI:1018;PHI:2042","MDR Transporter;multidrug resistance;protection from oxidative stress"]
["gene1314","PHI:673","Carbonic Anhydrase"]
["gene1315","PHI:2936","Response regulator involved in surface attachment, cellûcell aggregation, exopolysaccharide production and virulence"]
["gene1321","PHI:4584","virulence factor"]
["gene1322","PHI:384","Chimeric spermidine synthase/saccharopine dehydrogenase"]
["gene1331","PHI:6520","Effector (plant avirulence determinant)"]
["gene1334","PHI:3135","Part of the pyruvate - tricarboxylic acid cycle node"]
["gene1343","PHI:6362","Twitching motility"]
["gene1344","PHI:6363","Twitching motility"]
["gene1346","PHI:4071","Inosine-5'-monophosphate dehydrogenase"]
["gene1352","PHI:5240","Iron utilization"]
["gene1354","PHI:5346","Capsule"]
["gene1371","PHI:4961","Ribosomal RNA small subunit methyltransferase H"]
["gene1373","PHI:2672","Regulators of systemic infection"]
["gene1374","PHI:3976","Acetolactate synthases"]
["gene1376","PHI:3975","Acetolactate synthases"]
["gene1377","PHI:3975","Acetolactate synthases"]
["gene1380","PHI:504","beta-isopropyl-malate dehydrogenase"]
["gene1396","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene1399","PHI:3008","Putative response regulator"]
["gene1410","PHI:4224;PHI:4683","histidine kinase;Sensor kinase SaeS is a member of the intramembrane-sensing histidine kinases"]
["gene1417","PHI:2735","Posttranscriptional regulator"]
["gene1440","PHI:3267","Transcriptional activator protein"]
["gene1441","PHI:3266","Antiporter gene"]
["gene1442","PHI:6986","Heat shock protein. PI3K and JNK signalling pathway"]
["gene1457","PHI:3389","fusaric acid biosynthesis"]
["gene1460","PHI:6532","Aerobic respiration control protein"]
["gene1462","PHI:3709","Sensor protein QseC bacterial adrenergic receptor"]
["gene1463","PHI:2446","no data found"]
["gene1464","PHI:3615","Two-Component Regulatory Systems"]
["gene1471","PHI:1017;PHI:2067","multidrug resistance;ABC Transporter"]
["gene1476","PHI:6512","Lipoate protein ligase"]
["gene1499","PHI:6529","PTS chitobiose transporter subunit IIA"]
["gene1504","PHI:5404","4-HBA degradation pathway components"]
["gene1520","PHI:5256","Sigma-54 interaction domaincontaining protein"]
["gene1529","PHI:4840","DSF-Controlled Virulence-Associated Genes"]
["gene1535","PHI:2145","Succinate-semialdehyde dehydrogenase"]
["gene1548","PHI:3914","encodes succinic semialdehyde dehydrogenase"]
["gene1566","PHI:3028","MocR family of transcriptional regulators"]
["gene1590","PHI:4633","Diguanylate cyclase"]
["gene1592","PHI:6324","Cysteine protease"]
["gene1593","PHI:6324","Cysteine protease"]
["gene1604","PHI:3616","Two-Component Regulatory Systems"]
["gene1605","PHI:1144","Two-component system response regulatory required for Ax21 (synonym: AvrXa21)activity"]
["gene1606","PHI:6388","Multidrug efflux protein"]
["gene1609","PHI:6449","Multidrug efflux pump"]
["gene1618","PHI:2408","Sphingolipid C-9 Methyltransferases"]
["gene1643","PHI:5034","alcohol dehydrogenase"]
["gene1647","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene1661","PHI:2145","Succinate-semialdehyde dehydrogenase"]
["gene1673","PHI:2634","Ornithine carbamoyltransferase"]
["gene1674","PHI:5301","Regulators of N- acetyl- galactosamine utilization pathway"]
["gene1675","PHI:4180","arginine deiminase system"]
["gene1683","PHI:440","P-type ATPase transporter"]
["gene1687","PHI:6732","Trehalose synthase"]
["gene1720","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene1730","PHI:4580","Methionine Sulfoxide Reductase"]
["gene1739","PHI:7020","2?,3?-Cyclic phosphodiesterase"]
["gene1771","PHI:2625","Pathogenicity island"]
["gene1778","PHI:2687","Regulators of systemic infection"]
["gene1779","PHI:6266","tRNA dimethylallyltransferase"]
["gene1780","PHI:1616","transcription factor"]
["gene1790","PHI:6274","Oligoribonuclease"]
["gene1796","PHI:2960","Fumarate reductase"]
["gene1804","PHI:6420","Elongation factor"]
["gene1811","PHI:1018;PHI:2042","MDR Transporter;multidrug resistance;protection from oxidative stress"]
["gene1820","PHI:3085","folding of newly synthesized proteins, preventing misfolding and aggregation"]
["gene1842","PHI:3448","Production of poly-b-linkedN-acetylglucosamine"]
["gene1848","PHI:4733","no data found"]
["gene1869","PHI:4975","Functional Type 1 Secretion System"]
["gene1874","PHI:3796","regulates light affected growth"]
["gene1875","PHI:3928","ABC-Type Ef?ux Pump"]
["gene1883","PHI:2685","Regulators of systemic infection"]
["gene1902","PHI:5242","Regulates virulence determinant biosynthesis and pathogenesis"]
["gene1907","PHI:5370","Transcriptional regulator"]
["gene1908","PHI:3646","cyclic-di-GMP-specific phosphodiesterase"]
["gene1914","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene1924","PHI:5370","Transcriptional regulator"]
["gene1926","PHI:6654","Iron-regulated outer membrane virulence protein"]
["gene1929","PHI:2737","Single-stranded DNA-binding protein"]
["gene1956","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene1968","PHI:1772","transcription factor"]
["gene1970","PHI:3389","fusaric acid biosynthesis"]
["gene1980","PHI:305","Isocitrate lyase"]
["gene1981","PHI:4021","Malate synthase"]
["gene1989","PHI:744","Phosphoribosylamine-glycine ligase"]
["gene1991","PHI:3056","upstream negative regulator of smcR"]
["gene1992","PHI:6118","histidine kinase-response regulator hybrid protein"]
["gene1996","PHI:3074","Nucleoid-associated protein, is a basic DNA-binding protein involved in gene regulation"]
["gene2043","PHI:3689","3-ketoacyl-CoA thiolases"]
["gene2050","PHI:2417","virulence;Translocate folded proteins"]
["gene2051","PHI:2416","virulence;Translocate folded proteins"]
["gene2068","PHI:442","Methionine synthase"]
["gene2080","PHI:2479","Magnesium/nickel/cobalt transporter"]
["gene2090","PHI:2950","Adenylate cyclase gene responsible for cAMP synthesis"]
["gene2111","PHI:3728","chain length determinant"]
["gene2113","PHI:4613","Type III Secretion System"]
["gene2114","PHI:2644","Redox activity"]
["gene2115","PHI:6510","RNA Helicase"]
["gene2122","PHI:6137","Foldase"]
["gene2124","PHI:3092","activate gene expression in response to oxidative stress"]
["gene2125","PHI:3257","Threonine deaminase"]
["gene2130","PHI:3975","Acetolactate synthases"]
["gene2134","PHI:5089","LysR-Type Transcriptional Regulator"]
["gene2143","PHI:6654","Iron-regulated outer membrane virulence protein"]
["gene2150","PHI:3714","oxidative stress response regulator"]
["gene2151","PHI:2632","Argininosuccinate lyase"]
["gene2153","PHI:5233","Arginine biosynthesis"]
["gene2161","PHI:3714","oxidative stress response regulator"]
["gene2167","PHI:443","Cystathionine beta-lyase"]
["gene2168","PHI:2695","Repressor of the methionine biosynthesis regulon"]
["gene2172","PHI:2672","Regulators of systemic infection"]
["gene2183","PHI:4523","response regulator (CpxR)-sensor kinase"]
["gene2184","PHI:2686","Regulators of systemic infection"]
["gene2187","PHI:420","Superoxide dismutase"]
["gene2196","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene2227","PHI:562"]
["gene2228","PHI:4100","Quorum sensing"]
["gene2249","PHI:612"]
["gene2252","PHI:1017;PHI:2067","multidrug resistance;ABC Transporter"]
["gene2276","PHI:2513","Glutamine-fructose-6-phosphate aminotransferase"]
["gene2279","PHI:3635","PstA component of phosphate uptake"]
["gene2280","PHI:3412","phosphate metabolism"]
["gene2285","PHI:5472","GlcN-6-phosphate deaminase"]
["gene2314","PHI:2657","Functions as a VirB8 chaperone to promote T4SS-mediated DNA transfer"]
["gene2315","PHI:2660","Alpha-crystallin-type small heat shock proteins"]
["gene2319","PHI:6309","Glucose uptake protein"]
["gene2325","PHI:6700","Low-affinity permease"]
["gene2326","PHI:3491","Tobacco hypersensitive responses, grape necrosis"]
["gene2332","PHI:3975","Acetolactate synthases"]
["gene2334","PHI:5066","Response regulator"]
["gene2336","PHI:2473","Regulatory gene;part of the HrpX/HrpY Two-Component System"]
["gene2347","PHI:3135","Part of the pyruvate - tricarboxylic acid cycle node"]
["gene2350","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene2355","PHI:6529","PTS chitobiose transporter subunit IIA"]
["gene2372","PHI:6388","Multidrug efflux protein"]
["gene2373","PHI:6451","Acriflavine resistance protein"]
["gene2374","PHI:6386","Multidrug efflux protein"]
["gene2378","PHI:3055;PHI:4114","quorum sensing regulator;major QS regulator"]
["gene2379","PHI:1161","major facilitator superfamily transporter"]
["gene2380","PHI:5548","AphB and OhrR monitor redox-potential changes and respond with different kinetics"]
["gene2388","PHI:4915","Invasion and establishment of infection"]
["gene2409","PHI:6308","Glucose uptake protein"]
["gene2425","PHI:6483","DNA repair"]
["gene2427","PHI:6720","Bi-functional protein with (p)ppGpp synthetase and hydrolase domains"]
["gene2445","PHI:687","orotidine monophosphate pyrophosphorylase"]
["gene2451","PHI:4701","DNA repair"]
["gene2471","PHI:5347","Capsule"]
["gene2472","PHI:1130;PHI:2256","xylitol dehydrogenase"]
["gene2475","PHI:5573","Determinants for intrinsic CAMP resistance"]
["gene2484","PHI:3383","fusaric acid biosynthesis"]
["gene2485","PHI:3135","Part of the pyruvate - tricarboxylic acid cycle node"]
["gene2491","PHI:2249;PHI:2270","no data found;Mannitol-1-phosphate 5-dehydrogenase"]
["gene2503","PHI:6732","Trehalose synthase"]
["gene2507","PHI:6324","Cysteine protease"]
["gene2508","PHI:3928","ABC-Type Ef?ux Pump"]
["gene2522","PHI:6372","Cold shock protein"]
["gene2532","PHI:3937","putative ompa family outer membrane protein precursor"]
["gene2540","PHI:4910","PEA transferases"]
["gene2541","PHI:1260","protein kinase"]
["gene2547","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene2549","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene2572","PHI:3042","phosphodiesterases"]
["gene2574","PHI:4189","putative DNA binding protein"]
["gene2580","PHI:5548","AphB and OhrR monitor redox-potential changes and respond with different kinetics"]
["gene2581","PHI:5271","3-ketoacyl-acyl carrier protein reductase"]
["gene2583","PHI:6630","Trehalase"]
["gene2586","PHI:4904","Glutathione recycling enzymes/ glutathione reductase"]
["gene2600","PHI:3412","phosphate metabolism"]
["gene2609","PHI:3999","formyl methionyl transferase"]
["gene2620","PHI:5275","Copper homeostasis"]
["gene2621","PHI:5275","Copper homeostasis"]
["gene2627","PHI:3928","ABC-Type Ef?ux Pump"]
["gene2630","PHI:3336","regulation of stress and starvation response"]
["gene2632","PHI:3126","argDgene encodes a predicted N-acetylornithine aminotransferase enzyme"]
["gene2641","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene2642","PHI:6324","Cysteine protease"]
["gene2648","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene2651","PHI:3146","virulence determinants"]
["gene2657","PHI:6701","Thermo-resistant gluconate kinase"]
["gene2665","PHI:6731","Glucose-1-phosphate adenylyltransferase"]
["gene2670","PHI:3272","Glycerol-3-phosphate dehydrogenase involved in glycerol fermentation"]
["gene2673","PHI:6545","O-Antigen Capsule"]
["gene2674","PHI:3620","Two-Component Regulatory Systems"]
["gene2677","PHI:6700","Low-affinity permease"]
["gene2684","PHI:6941","Ferrous iron transport protein"]
["gene2686","PHI:3878","polynucleotide phosphorylase, an exoribonuclease involved in RNA processing and degradation"]
["gene2688","PHI:2685","Regulators of systemic infection"]
["gene2689","PHI:2686","Regulators of systemic infection"]
["gene2690","PHI:424","Phosphoenolpyruvate carboxykinase"]
["gene2704","PHI:3827","The ligands for TNF-a and IL-8 in a glycan-dependent manner, and their del-etion results in decreased virulence and increased survival in a mouse model"]
["gene2706","PHI:4250","3-dehydroquinate synthase"]
["gene2707","PHI:6729","Cell division protein"]
["gene2723","PHI:3126","argDgene encodes a predicted N-acetylornithine aminotransferase enzyme"]
["gene2727","PHI:2684","Regulators of systemic infection"]
["gene2732","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene2738","PHI:4583","virulence factor"]
["gene2743","PHI:1599","transcription factor"]
["gene2756","PHI:1569","transcription factor"]
["gene2773","PHI:5257","Protein translocase subunit SecY"]
["gene2784","PHI:2694","Modulates plant cell wallûdegrading enzymes"]
["gene2785","PHI:3999","formyl methionyl transferase"]
["gene2802","PHI:6451","Acriflavine resistance protein"]
["gene2803","PHI:6386","Multidrug efflux protein"]
["gene2812","PHI:1385","transcription factor"]
["gene2823","PHI:3723","endoribonucleases"]
["gene2835","PHI:2959","Malate dehydrogenase"]
["gene2836","PHI:6358","Protease"]
["gene2837","PHI:6358","Protease"]
["gene2854","PHI:562"]
["gene2860","PHI:3133","Part of the pyruvate - tricarboxylic acid cycle node"]
["gene2861","PHI:3674;PHI:3680","a novel ribosome-associated modulation protein"]
["gene2862","PHI:2906;PHI:3673;PHI:3679","a nitrogen limitation sigma factor;Sigma factor, regulating essential virulence gene expression"]
["gene2863","PHI:6324","Cysteine protease"]
["gene2890","PHI:1566","transcription factor"]
["gene2900","PHI:5232","Arginine biosynthesis"]
["gene2904","PHI:6281","Pneumococcal surface protein K"]
["gene2909","PHI:3878","polynucleotide phosphorylase, an exoribonuclease involved in RNA processing and degradation"]
["gene2911","PHI:6510","RNA Helicase"]
["gene2944","PHI:4960","Ribosomal RNA small subunit methyltransferase I"]
["gene2988","PHI:6894","Sulfur mobilization"]
["gene2994","PHI:3126","argDgene encodes a predicted N-acetylornithine aminotransferase enzyme"]
["gene2997","PHI:4026","siderophore-i nteracting protein"]
["gene3006","PHI:4629","IbeR controlled expression of stress-resistance genes and virulence genes."]
["gene3022","PHI:599","Putative histidine sensor kinase"]
["gene3023","PHI:3619","Two-Component Regulatory Systems"]
["gene3066","PHI:3336","regulation of stress and starvation response"]
["gene3075","PHI:3145","virulence determinants"]
["gene3076","PHI:4555","Urease"]
["gene3077","PHI:4555","Urease"]
["gene3091","PHI:3147","Part of cluster invloved in lipooligosaccharide synthesis"]
["gene3092","PHI:3147","Part of cluster invloved in lipooligosaccharide synthesis"]
["gene3095","PHI:6697","Membrane fusogenic activity"]
["gene3101","PHI:4996","outer membrane protein"]
["gene3109","PHI:6883","Two-component system sensor histidine kinase"]
["gene3110","PHI:6882","Two-component system response regulator"]
["gene3113","PHI:824","DNA gyrase (bacterial topoisomerase II)"]
["gene3114","PHI:6380","Lysophosphatidate acyltransferase"]
["gene3141","PHI:3385","fusaric acid biosynthesis"]
["gene3156","PHI:3928","ABC-Type Ef?ux Pump"]
["gene3163","PHI:6363","Twitching motility"]
["gene3165","PHI:4690","Orphan response regulator"]
["gene3172","PHI:6381","inositol transporter"]
["gene3174","PHI:877","Hypothetical protein"]
["gene3182","PHI:6904","Glyceraldehyde-3-phosphate dehydrogenase"]
["gene3184","PHI:6903","Fructose-bisphosphate aldolase"]
["gene3196","PHI:7028","Aerobic ubiquinone-8 synthase"]
["gene3197","PHI:7028","Aerobic ubiquinone-8 synthase"]
["gene3201","PHI:2961","Glycine dehydrogenase"]
["gene3202","PHI:5271","3-ketoacyl-acyl carrier protein reductase"]
["gene3219","PHI:4652","Manganese Homeostasis"]
["gene3220","PHI:1594","transcription factor"]
["gene3230","PHI:3491","Tobacco hypersensitive responses, grape necrosis"]
["gene3240","PHI:6388","Multidrug efflux protein"]
["gene3243","PHI:6448","RND family efflux transporter"]
["gene3247","PHI:6511","Pilus regulatory gene"]
["gene3248","PHI:6511","Pilus regulatory gene"]
["gene3249","PHI:2690","Adhesion"]
["gene3262","PHI:4176","virulence negative regulators"]
["gene3265","PHI:6099","Ferrous iron transporter"]
["gene3269","PHI:6099","Ferrous iron transporter"]
["gene3277","PHI:5082","Acetyl-CoA acetyltransferas"]
["gene3281","PHI:2034","beta-oxidation"]
["gene3282","PHI:6381","inositol transporter"]
["gene3290","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene3298","PHI:4564","global transcriptional regulator of carbon catabolite repression"]
["gene3299","PHI:6529","PTS chitobiose transporter subunit IIA"]
["gene3305","PHI:508","AF-toxin biosynthesis"]
["gene3306","PHI:6938;PHI:6989","Iron siderophore;Pyochelin biosynthesis protein"]
["gene3372","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene3383","PHI:4210","Nitrogen fixation protein"]
["gene3388","PHI:6503","Fructose metabolism"]
["gene3392","PHI:3663","Glucose kinase, Glk"]
["gene3397","PHI:4028","Alkanesulphonate -Binding Protein"]
["gene3398","PHI:3219","Flagellar motility"]
["gene3404","PHI:3928","ABC-Type Ef?ux Pump"]
["gene3411","PHI:4028","Alkanesulphonate -Binding Protein"]
["gene3425","PHI:562"]
["gene3426","PHI:562"]
["gene3428","PHI:4166","CT production"]
["gene3432","PHI:6531","Hemolysin"]
["gene3441","PHI:1138","Sulfate adenylyltransferase (ATP) required for Ax21 activity"]
["gene3443","PHI:265","ATP sulfurylase"]
["gene3450","PHI:6187","Protein isoaspartate methyl transferase"]
["gene3452","PHI:2683","Regulators of systemic infection"]
["gene3456","PHI:3092","activate gene expression in response to oxidative stress"]
["gene3465","PHI:1018;PHI:2042","MDR Transporter;multidrug resistance;protection from oxidative stress"]
["gene3466","PHI:6849","ABC transporter"]
["gene3469","PHI:6944","Haem/Haemoglobin uptake outer membrane receptor"]
["gene3478","PHI:3928","ABC-Type Ef?ux Pump"]
["gene3483","PHI:6529","PTS chitobiose transporter subunit IIA"]
["gene3485","PHI:6529","PTS chitobiose transporter subunit IIA"]
["gene3489","PHI:3219","Flagellar motility"]
["gene3509","PHI:4631","Transcription Regulator"]
["gene3513","PHI:6850","High-affinity nickel-transport protein"]
["gene3517","PHI:3219","Flagellar motility"]
["gene3518","PHI:3056","upstream negative regulator of smcR"]
["gene3532","PHI:4702","DNA recombination and repair"]
["gene3535","PHI:2682","Regulators of systemic infection"]
["gene3545","PHI:3731","controller in the Quorum sensing"]
["gene3553","PHI:5407","Transcriptional repressor of an operon encoding the EmrAB efflux pump."]
["gene3559","PHI:3412","phosphate metabolism"]
["gene3571","PHI:6097","pleiotropic regulator"]
["gene3579","PHI:3978","T6SS effector"]
["gene3597","PHI:3412","phosphate metabolism"]
["gene3598","PHI:3412","phosphate metabolism"]
["gene3606","PHI:6449","Multidrug efflux pump"]
["gene3607","PHI:6448","RND family efflux transporter"]
["gene3608","PHI:5370","Transcriptional regulator"]
["gene3610","PHI:5548","AphB and OhrR monitor redox-potential changes and respond with different kinetics"]
["gene3622","PHI:2681","Regulators of systemic infection"]
["gene3646","PHI:3675;PHI:3681","no data found"]
["gene3651","PHI:4559","Type VI secretion systems (T6SSs) effectors"]
["gene3661","PHI:5571;PHI:6366","Protein lysine acetyltransferase;acetyltransferase"]
["gene3662","PHI:5571;PHI:6366","Protein lysine acetyltransferase;acetyltransferase"]
["gene3663","PHI:5571;PHI:6366","Protein lysine acetyltransferase;acetyltransferase"]
["gene3665","PHI:2644","Redox activity"]
["gene3671","PHI:6510","RNA Helicase"]
["gene3673","PHI:2960","Fumarate reductase"]
["gene3674","PHI:2680","Regulators of systemic infection"]
["gene3681","PHI:3724","endoribonucleases"]
["gene3694","PHI:3592","encoding the histidine sensor kinase of the two-component system RfpC/RpfG"]
["gene3696","PHI:3011","Sensor protein"]
["gene3697","PHI:3219","Flagellar motility"]
["gene3699","PHI:2304","NO detoxi?cation"]
["gene3700","PHI:2962","Serine h ydroxymethyltra nsferase"]
["gene3705","PHI:2968","Glucose uptake and transport"]
["gene3714","PHI:6895","FeûS cluster sensor"]
["gene3716","PHI:6892","FeûS cluster sensor"]
["gene3725","PHI:609;PHI:616",";Type III secretion"]
["gene3726","PHI:609;PHI:616",";Type III secretion"]
["gene3730","PHI:3945","Nucleotide diphosphate kinase"]
["gene3738","PHI:6941","Ferrous iron transport protein"]
["gene3743","PHI:4071","Inosine-5'-monophosphate dehydrogenase"]
["gene3744","PHI:6871","GMP synthase"]
["gene3751","PHI:3042","phosphodiesterases"]
["gene3753","PHI:5063","Polyphosphate kinase"]
["gene3755","PHI:744","Phosphoribosylamine-glycine ligase"]
["gene3778","PHI:4043","a resistance-nodulation-cell division (RND) transporter"]
["gene3789","PHI:6516","Phosphate acetyltransferase"]
["gene3803","PHI:5299","HTH-type transcriptional regulator;autotransporter"]
["gene3804","PHI:5299","HTH-type transcriptional regulator;autotransporter"]
["gene3813","PHI:6321","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene3815","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene3822","PHI:6308","Glucose uptake protein"]
["gene3835","PHI:3092","activate gene expression in response to oxidative stress"]
["gene3846","PHI:3042","phosphodiesterases"]
["gene3856","PHI:3008","Putative response regulator"]
["gene3857","PHI:6896","virulence related two-component system"]
["gene3864","PHI:5548","AphB and OhrR monitor redox-potential changes and respond with different kinetics"]
["gene3871","PHI:6900","virulence related outer membrane lipoprotein"]
["gene3874","PHI:5082","Acetyl-CoA acetyltransferas"]
["gene3886","PHI:724;PHI:730","Polyketide synthase"]
["gene3898","PHI:502","Amidophosphoribosyltransferase"]
["gene3905","PHI:3412","phosphate metabolism"]
["gene3914","PHI:6516","Phosphate acetyltransferase"]
["gene3926","PHI:5089","LysR-Type Transcriptional Regulator"]
["gene3927","PHI:5089","LysR-Type Transcriptional Regulator"]
["gene3931","PHI:445","Ubiquinone oxidoreductase"]
["gene3975","PHI:824","DNA gyrase (bacterial topoisomerase II)"]
["gene3976","PHI:3011","Sensor protein"]
["gene3977","PHI:4164","govern the expression of cps and of the loci implicated in lipid A remodeling"]
["gene3978","PHI:2501","Phosphorelay system"]
["gene3980","PHI:4161","outer membrane proteins"]
["gene3984","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene3987","PHI:6190","malate-quinone oxidoreductases"]
["gene3988","PHI:4101","serine protease inhibitor"]
["gene4004","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4008","PHI:4684","Global/motility Regulator"]
["gene4015","PHI:3953","Elongation factor P"]
["gene4021","PHI:6527","Phosphofructokinase"]
["gene4025","PHI:3793","encode alpha -(1û6)-mannosyl-transferases"]
["gene4030","PHI:6654","Iron-regulated outer membrane virulence protein"]
["gene4034","PHI:4564","global transcriptional regulator of carbon catabolite repression"]
["gene4036","PHI:2815","ATP binding cassette trans-porter of the plasma membrane implicated in general cellular detoxi?cation"]
["gene4045","PHI:4630","Transcription Regulator"]
["gene4046","PHI:4631","Transcription Regulator"]
["gene4047","PHI:6308","Glucose uptake protein"]
["gene4050","PHI:6388","Multidrug efflux protein"]
["gene4057","PHI:24","Avenacinase"]
["gene4061","PHI:3412","phosphate metabolism"]
["gene4066","PHI:6994","Global regulator"]
["gene4118","PHI:4975","Functional Type 1 Secretion System"]
["gene4119","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4122","PHI:6964","Putative collagenase"]
["gene4123","PHI:2685","Regulators of systemic infection"]
["gene4124","PHI:3211;PHI:3212","two-component sensor kinase"]
["gene4127","PHI:6449","Multidrug efflux pump"]
["gene4128","PHI:6449","Multidrug efflux pump"]
["gene4129","PHI:6449","Multidrug efflux pump"]
["gene4130","PHI:6448","RND family efflux transporter"]
["gene4135","PHI:6110","Part of the two-component system PhoP-PhoQ that regulates virulence"]
["gene4142","PHI:2652","Contributes to K1 capsular polysaccharide (CPS) biosynthesis"]
["gene4147","PHI:3112","Uridine triphosphate (UTP)-glucose-1-phosphate uridylyltransferase"]
["gene4153","PHI:2471","Exopolysaccharides Amylovoran"]
["gene4166","PHI:2937","no data found"]
["gene4169","PHI:387","UDP-glucose dehydrogenase"]
["gene4174","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4179","PHI:6140","Glycosyltransferases"]
["gene4181","PHI:6142","Resistance to a Wall teichoic acid (WTA)-binding bacteriophage"]
["gene4187","PHI:2516;PHI:6441","Imidazole-glycerol-phosphate dehydratase;Histidine biosynthesis"]
["gene4191","PHI:5109","OAg biosynthesis"]
["gene4193","PHI:2669","LysR-type transcriptional regulators"]
["gene4214","PHI:4684","Global/motility Regulator"]
["gene4221","PHI:3042","phosphodiesterases"]
["gene4235","PHI:5242","Regulates virulence determinant biosynthesis and pathogenesis"]
["gene4236","PHI:5242","Regulates virulence determinant biosynthesis and pathogenesis"]
["gene4243","PHI:4161","outer membrane proteins"]
["gene4252","PHI:3042","phosphodiesterases"]
["gene4255","PHI:3013","Positive regulator of capsular polysaccharide synthesis. RcsA and RcsB form a complex to promote transcription of the genes for capsule synthesis."]
["gene4261","PHI:3928","ABC-Type Ef?ux Pump"]
["gene4262","PHI:6748;PHI:6996","QSS regulatory protein;Acyl-homoserine-lactone-dependent quorum sensing system"]
["gene4264","PHI:560"]
["gene4286","PHI:6913","ATP Binding Cassette Protein"]
["gene4289","PHI:4144;PHI:4627","trehalose-6-phosphate synthase;Trehalose-6-phosphate synthase"]
["gene4306","PHI:6447","Holliday junction DNA helicase"]
["gene4307","PHI:5013","zinc transporter"]
["gene4308","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4310","PHI:4185","putative DNA binding protein"]
["gene4312","PHI:6684","Pyruvate kinase"]
["gene4316","PHI:6698","6-Phosphogluconate dehydratase"]
["gene4321","PHI:2580;PHI:2601","Oligopeptidase B functions as a processing enzyme, generating an active Ca2 agonist from a cytosolic precursor molecule"]
["gene4338","PHI:5547","Tail-specific protease"]
["gene4341","PHI:4175","virulence negative regulators"]
["gene4346","PHI:6372","Cold shock protein"]
["gene4358","PHI:3646","cyclic-di-GMP-specific phosphodiesterase"]
["gene4366","PHI:6870","Resuscitation-promoting factor"]
["gene4368","PHI:6991","Iron siderophore"]
["gene4381","PHI:6702","Regulatory molecule"]
["gene4390","PHI:6373","ferrichrome receptor"]
["gene4392","PHI:6630","Trehalase"]
["gene4404","PHI:3257","Threonine deaminase"]
["gene4405","PHI:3257","Threonine deaminase"]
["gene4412","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4413","PHI:3412","phosphate metabolism"]
["gene4414","PHI:3714","oxidative stress response regulator"]
["gene4415","PHI:424","Phosphoenolpyruvate carboxykinase"]
["gene4420","PHI:3092","activate gene expression in response to oxidative stress"]
["gene4432","PHI:4558","Type VI secretion systems (T6SSs) effectors"]
["gene4433","PHI:4558","Type VI secretion systems (T6SSs) effectors"]
["gene4459","PHI:4732","ribose phosphate pyrophosphokinase"]
["gene4463","PHI:4652","Manganese Homeostasis"]
["gene4478","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4481","PHI:6184","invasin homolog"]
["gene4482","PHI:3620","Two-Component Regulatory Systems"]
["gene4497","PHI:3011","Sensor protein"]
["gene4498","PHI:3112","Uridine triphosphate (UTP)-glucose-1-phosphate uridylyltransferase"]
["gene4499","PHI:6097","pleiotropic regulator"]
["gene4510","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4511","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4523","PHI:6651","siderophores synthesis"]
["gene4536","PHI:3074","Nucleoid-associated protein, is a basic DNA-binding protein involved in gene regulation"]
["gene4541","PHI:6849","ABC transporter"]
["gene4543","PHI:4936","Glutathione peroxidase"]
["gene4556","PHI:6270","Proofreading thioesterase"]
["gene4562","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4572","PHI:2570","Lactate dehydrogenase"]
["gene4575","PHI:6893","Sulfur mobilization"]
["gene4576","PHI:6894","Sulfur mobilization"]
["gene4577","PHI:6894","Sulfur mobilization"]
["gene4583","PHI:3134","Part of the pyruvate - tricarboxylic acid cycle node"]
["gene4586","PHI:603"]
["gene4593","PHI:1017;PHI:2067","multidrug resistance;ABC Transporter"]
["gene4594","PHI:6849","ABC transporter"]
["gene4613","PHI:5242","Regulates virulence determinant biosynthesis and pathogenesis"]
["gene4620","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4622","PHI:267","ABC transporter"]
["gene4632","PHI:3412","phosphate metabolism"]
["gene4646","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4663","PHI:3618","Two-Component Regulatory Systems"]
["gene4664","PHI:5466","Bacterial two component system, SrrAB, which is known to help S. aureussurvive in low oxygen"]
["gene4667","PHI:6264","RND MDR efflux system"]
["gene4668","PHI:6264","RND MDR efflux system"]
["gene4670","PHI:5271","3-ketoacyl-acyl carrier protein reductase"]
["gene4675","PHI:5440","Abscisic Acid production"]
["gene4678","PHI:5083","Acetyl-CoA acetyltransferas"]
["gene4699","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4719","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4720","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4729","PHI:6545","O-Antigen Capsule"]
["gene4750","PHI:2643","Cyclopropane fatty acid synthetase"]
["gene4759","PHI:414","Glyoxalase"]
["gene4767","PHI:6448","RND family efflux transporter"]
["gene4769","PHI:2678","Regulators of systemic infection"]
["gene4770","PHI:4663","Diguanylate cyclase"]
["gene4773","PHI:2646","Lysozyme inhibitor"]
["gene4790","PHI:4179","synthesis and perception of signaling molecules"]
["gene4802","PHI:3277","S-nitrosoglutathione reductase"]
["gene4804","PHI:5242","Regulates virulence determinant biosynthesis and pathogenesis"]
["gene4808","PHI:541","Lipase"]
["gene4809","PHI:668","GSNO reductase"]
["gene4811","PHI:5564","Glucans biosynthesis protein"]
["gene4825","PHI:6964","Putative collagenase"]
["gene4834","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4836","PHI:6320","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4837","PHI:6321","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4840","PHI:2145","Succinate-semialdehyde dehydrogenase"]
["gene4846","PHI:2145","Succinate-semialdehyde dehydrogenase"]
["gene4853","PHI:2839","Reductase"]
["gene4859","PHI:4955","Iron binding"]
["gene4866","PHI:5548","AphB and OhrR monitor redox-potential changes and respond with different kinetics"]
["gene4874","PHI:3412","phosphate metabolism"]
["gene4886","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4919","PHI:3634","Unknown, possible transcriptional regulator"]
["gene4924","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4928","PHI:6517","Alcohol dehydrogenase"]
["gene4931","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene4945","PHI:6732","Trehalose synthase"]
["gene4961","PHI:3092","activate gene expression in response to oxidative stress"]
["gene4964","PHI:3668;PHI:4693;PHI:4698","Required for intramacrophage survival and growth in low Mg2+.;Virulence protein;cellulose synthesis regulation"]
["gene4967","PHI:6089","catalase-peroxidase"]
["gene4984","PHI:2685","Regulators of systemic infection"]
["gene4985","PHI:3211;PHI:3212","two-component sensor kinase"]
["gene4986","PHI:3211;PHI:3212","two-component sensor kinase"]
["gene4989","PHI:5089","LysR-Type Transcriptional Regulator"]
["gene4992","PHI:3126","argDgene encodes a predicted N-acetylornithine aminotransferase enzyme"]
["gene4995","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene5005","PHI:4663","Diguanylate cyclase"]
["gene5026","PHI:724;PHI:730","Polyketide synthase"]
["gene5034","PHI:4171","biosynthesis of IAA"]
["gene5042","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene5043","PHI:3928","ABC-Type Ef?ux Pump"]
["gene5047","PHI:5548","AphB and OhrR monitor redox-potential changes and respond with different kinetics"]
["gene5075","PHI:3472","Periplasm spanning protein"]
["gene5080","PHI:4975","Functional Type 1 Secretion System"]
["gene5081","PHI:2672","Regulators of systemic infection"]
["gene5091","PHI:3617","Two-Component Regulatory Systems"]
["gene5092","PHI:606","tetrathionate reductase"]
["gene5098","PHI:419","Cell surface protein"]
["gene5102","PHI:6904","Glyceraldehyde-3-phosphate dehydrogenase"]
["gene5112","PHI:6545","O-Antigen Capsule"]
["gene5117","PHI:4837","Phytotoxic Cyclic Lipodepsipeptides"]
["gene5119","PHI:5271","3-ketoacyl-acyl carrier protein reductase"]
["gene5120","PHI:3689","3-ketoacyl-CoA thiolases"]
["gene5130","PHI:4631","Transcription Regulator"]
["gene5137","PHI:4861","Catecholate siderophore esterases"]
["gene5138","PHI:4684","Global/motility Regulator"]
["gene5155","PHI:413","Mannitol 1-phosphate dehydrogenase"]
["gene5166","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene5182","PHI:3042","phosphodiesterases"]
["gene5185","PHI:2145","Succinate-semialdehyde dehydrogenase"]
["gene5188","PHI:4140","Redox Balance"]
["gene5189","PHI:6503","Fructose metabolism"]
["gene5202","PHI:5370","Transcriptional regulator"]
["gene5207","PHI:3412","phosphate metabolism"]
["gene5209","PHI:6324","Cysteine protease"]
["gene5220","PHI:6268","Beta-galactosidase"]
["gene5231","PHI:6700","Low-affinity permease"]
["gene5235","PHI:5504","RpfFBc/RpfR system is involved in sensing and responding to DSF signals"]
["gene5258","PHI:604","tetrathionate reductase"]
["gene5288","PHI:6190","malate-quinone oxidoreductases"]
["gene5289","PHI:6190","malate-quinone oxidoreductases"]
["gene5294","PHI:4523","response regulator (CpxR)-sensor kinase"]
["gene5306","PHI:5083","Acetyl-CoA acetyltransferas"]
["gene5309","PHI:4175","virulence negative regulators"]
["gene5311","PHI:5548","AphB and OhrR monitor redox-potential changes and respond with different kinetics"]
["gene5317","PHI:4876","global regulator"]
["gene5330","PHI:3482","response regulator"]
["gene5334","PHI:2686","Regulators of systemic infection"]
["gene5339","PHI:220","Phosphomannose isomerase"]
["gene5343","PHI:4631","Transcription Regulator"]
["gene5352","PHI:6904","Glyceraldehyde-3-phosphate dehydrogenase"]
["gene5353","PHI:2145","Succinate-semialdehyde dehydrogenase"]
["gene5362","PHI:3126","argDgene encodes a predicted N-acetylornithine aminotransferase enzyme"]
["gene5367","PHI:3714","oxidative stress response regulator"]
["gene5372","PHI:6448","RND family efflux transporter"]
["gene5373","PHI:6388","Multidrug efflux protein"]
["gene5375","PHI:1579","transcription factor"]
["gene5381","PHI:598","3-ketoacyl-CoA thiolase"]
["gene5382","PHI:5082","Acetyl-CoA acetyltransferas"]
["gene5387","PHI:2322","Anoyl-CoA hydratase"]
["gene5388","PHI:3172","phenylacetic acid catabolism"]
["gene5389","PHI:3171","phenylacetic acid catabolism"]
["gene5391","PHI:3170","phenylacetic acid catabolism"]
["gene5392","PHI:3168","Transcriptional regulators involved in morphological switching in dimorphic fungal pathogens."]
["gene5408","PHI:4161","outer membrane proteins"]
["gene5409","PHI:2872","Outer membrane protein"]
["gene5415","PHI:6510","RNA Helicase"]
["gene5417","PHI:6545","O-Antigen Capsule"]
["gene5423","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene5428","PHI:2175","Corepressor to control virulence-associated gene expression downstream of Tps1"]
["gene5431","PHI:5548","AphB and OhrR monitor redox-potential changes and respond with different kinetics"]
["gene5436","PHI:5271","3-ketoacyl-acyl carrier protein reductase"]
["gene5467","PHI:4558","Type VI secretion systems (T6SSs) effectors"]
["gene5468","PHI:4559","Type VI secretion systems (T6SSs) effectors"]
["gene5486","PHI:5548","AphB and OhrR monitor redox-potential changes and respond with different kinetics"]
["gene5494","PHI:4563","regulator of aromatic amino acid metabolism"]
["gene5504","PHI:3219","Flagellar motility"]
["gene5584","PHI:6319","ABC transporter ATP-binding protein - spermidine/putrescine transport"]
["gene5591","PHI:1568","transcription factor"]
["gene5608","PHI:3092","activate gene expression in response to oxidative stress"]
["gene5614","PHI:6957","Dehydrogenase"]
["gene5624","PHI:2517","Tryptophan synthase"]
["gene5625","PHI:2517","Tryptophan synthase"]
["gene5631","PHI:6373","ferrichrome receptor"]
["gene5637","PHI:6654","Iron-regulated outer membrane virulence protein"]
["gene5641","PHI:5440","Abscisic Acid production"]
["gene5645","PHI:6090","Hydroperoxidase"]
["gene5650","PHI:6529","PTS chitobiose transporter subunit IIA"]
["gene5661","PHI:3126","argDgene encodes a predicted N-acetylornithine aminotransferase enzyme"]
["gene5662","PHI:3126","argDgene encodes a predicted N-acetylornithine aminotransferase enzyme"]
["gene5676","PHI:2895","Polyketide synthetase protein"]
["gene5689","PHI:6904","Glyceraldehyde-3-phosphate dehydrogenase"]
["gene5698","PHI:2153;PHI:2356","Plant virulence;no data found"]
["gene5703","PHI:5440","Abscisic Acid production"]
["gene5754","PHI:5504","RpfFBc/RpfR system is involved in sensing and responding to DSF signals"]
["gene5759","PHI:3787","acyltransferases"]
["gene5764","PHI:3230","c-di-GMPphosphodiesterases"]
["gene5765","PHI:6109","GdpX1 inhibits virulence in rice and T3SS-related gene transcription"]
["gene5766","PHI:3714","oxidative stress response regulator"]
["gene5769","PHI:5504","RpfFBc/RpfR system is involved in sensing and responding to DSF signals"]
["gene5781","PHI:1130;PHI:2256","xylitol dehydrogenase"]

{"sheet":"Secretion systems","index":3,"n_rows":52,"n_cols":5,"rows_kept":52}
["Excel S2. Human disease-related systems of the K. pneumoniae NKU_KlebA1. Secretion systems (D)."]
["Gene ID","Description","Pathway Gene Name","KO ID","Type"]
["gene0647"," sec-independent protein translocase tatE","tatE","K03425","Tat Secretion System"]
["gene1049"," preprotein translocase subunit SecF","secF","K03074","Sec-SRP Secretion System"]
["gene1050"," preprotein translocase subunit SecD","secD","K03072","Sec-SRP Secretion System"]
["gene1051"," preprotein translocase subunit SecD","secD","K03072","Sec-SRP Secretion System"]
["gene1052"," preprotein translocase subunit YajC","yajC","K03210","Sec-SRP Secretion System"]
["gene1278"," Pullulanase secretion protein PulS","gspS","K02465","Type II Secretion System"]
["gene1282"," type II secretion system protein GspC","gspC","K02452","Type II Secretion System"]
["gene1283"," type II secretion system protein GspD","gspD","K02453","Type II Secretion System"]
["gene1284"," type II secretion system protein GspD","gspD","K02453","Type II Secretion System"]
["gene1285"," type II secretion system protein GspE","gspE","K02454","Type II Secretion System"]
["gene1286"," type II secretion system protein GspF","gspF","K02455","Type II Secretion System"]
["gene1287"," type II secretion system protein GspG","gspG","K02456","Type II Secretion System"]
["gene1288"," Pullulanase G protein","gspG","K02456","Type II Secretion System"]
["gene1289"," type II secretion system protein GspH","gspH","K02457","Type II Secretion System"]
["gene1290"," type II secretion system protein GspI","gspI","K02458","Type II Secretion System"]
["gene1291"," type II secretion system protein GspJ","gspJ","K02459","Type II Secretion System"]
["gene1292"," general secretion pathway protein K","gspK","K02460","Type II Secretion System"]
["gene1293"," type II secretion system protein L","gspL","K02461","Type II Secretion System"]
["gene1294"," type II secretion system protein GspL","gspL","K02461","Type II Secretion System"]
["gene1295"," general secretion pathway protein GspM","gspM","K02462","Type II Secretion System"]
["gene1297"," prepilin peptidase","gspO","K02464","Type II Secretion System"]
["gene1352"," protein translocase subunit SecA","secA","K03070","Sec-SRP Secretion System"]
["gene1353"," SecA regulator SecM","secM","K13301","Sec-SRP Secretion System"]
["gene2022"," preprotein translocase subunit SecE","secE","K03073","Sec-SRP Secretion System"]
["gene2050"," preprotein translocase subunit TatC","tatC","K03118","Tat Secretion System"]
["gene2051"," sec-independent translocase","tatB","K03117","Tat Secretion System"]
["gene2052"," protein translocase TatA","tatA","K03116","Tat Secretion System"]
["gene2295"," protein translocase component YidC","yidC","K03217","Sec-SRP Secretion System"]
["gene2480"," protein-export protein SecB","secB","K03071","Sec-SRP Secretion System"]
["gene2626"," signal recognition particle-docking protein FtsY","ftsY","K03110","Sec-SRP Secretion System"]
["gene2773"," preprotein translocase subunit SecY","secY","K03076","Sec-SRP Secretion System"]
["gene2893"," preprotein translocase subunit SecG","secG","K03075","Sec-SRP Secretion System"]
["gene3101"," outer membrane channel precursor protein","tolC","K12340","Type I Secretion System"]
["gene3464"," aminoacyl-histidine dipeptidase","hcp","K11903","Type VI Secretion System"]
["gene3632"," signal recognition particle protein","ffh","K03106","Sec-SRP Secretion System"]
["gene4428"," type VI secretion system protein ImpK","impK","K11892","Type VI Secretion System"]
["gene4434"," type IV secretion protein Rhs","vgrG","K11904","Type VI Secretion System"]
["gene4441"," type VI secretion protein VasK","impL","K11891","Type VI Secretion System"]
["gene4442"," type VI secretion protein VasK","impL","K11891","Type VI Secretion System"]
["gene4447"," type VI secretion protein","vasD","K11906","Type VI Secretion System"]
["gene5442"," type VI secretion system-associated lipoprotein","vasD","K11906","Type VI Secretion System"]
["gene5447"," type VI secretion protein VasK","impL","K11891","Type VI Secretion System"]
["gene5448"," type VI secretion protein VasK","impL","K11891","Type VI Secretion System"]
["gene5449"," type VI secretion protein VasK","impL","K11891","Type VI Secretion System"]
["gene5450"," type VI secretion system protein ImpL","impL","K11891","Type VI Secretion System"]
["gene5451"," type VI secretion protein VasK","impL","K11891","Type VI Secretion System"]
["gene5467"," type IV secretion protein Rhs","vgrG","K11904","Type VI Secretion System"]
["gene5468"," ClpV1 family T6SS ATPase","vasG","K11907","Type VI Secretion System"]
["gene5469"," type VI secretion system effector","hcp","K11903","Type VI Secretion System"]
["gene5471"," membrane protein","impK","K11892","Type VI Secretion System"]